(2-Amino-5-chloro-phenyl)-phenyl-methanol

Base Information

• Chemical Name: (2-Amino-5-chloro-phenyl)-phenyl-methanol
• CAS No.: 7039-50-1
• Molecular Formula: C₁₃H₁₂ClNO
• Molecular Weight: 233.697
• Hs Code.: 2922199090
• European Community (EC) Number: 811-640-2
• DSSTox Substance ID: DTXSID20377842
• Nikkaji Number: J763.310F
• Mol file: 7039-50-1.mol

Synonyms:(2-amino-5-chlorophenyl)(phenyl)methanol;7039-50-1;(2-Amino-5-chloro-phenyl)-phenyl-methanol;2-Amino-5-chlorobenzhydrol;(2-amino-5-chlorophenyl)-phenylmethanol;Cambridge id 5686860;Oprea1_279439;SCHEMBL9567857;DTXSID20377842;HMS1648I18;2-Amino-5-chlorophenylphenylmethanol;BBL008025;MFCD01004640;STK345033;AKOS000108623;AKOS016037103;VS-01789;BB 0216462;EN300-50099;AB00093521-01;SR-01000596893;SR-01000596893-1;BRD-A30460102-001-01-2;Z57157518;F0013-1176

Chemical Property of (2-Amino-5-chloro-phenyl)-phenyl-methanol

Chemical Property:

• PSA: 46.25000
• LogP: 3.58510
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 233.0607417
• Heavy Atom Count: 16
• Complexity: 218

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-5-chlorobenzhydrol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=C(C=CC(=C2)Cl)N)O

Technology Process of (2-Amino-5-chloro-phenyl)-phenyl-methanol

There total 10 articles about (2-Amino-5-chloro-phenyl)-phenyl-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-chloro-2-aminobenzophenone (719-59-5) → (2-amino-5-chlorophenyl)(phenyl)methanol (1159372-20-9,7039-50-1)

Guidance literature:

With sodium tetrahydroborate; In isopropyl alcohol; at 60 ℃; for 3.5h;

DOI:10.1134/S1070428006090314

Reference yield: 60.0%

5-chloro-2-aminobenzophenone (719-59-5) → (S)-(+)-2-amino-5-chlorobenzhydrol (127854-40-4,7039-50-1)

Guidance literature:

With yeast Rhodosporidium toruloides; at 30 ℃; for 168h; Product distribution; other benzophenones; Tween 80 and other dispersing agents;

DOI:10.1248/cpb.39.2498

Reference yield: 57.0%

(2-amino-5-chlorophenyl)(phenyl)methanol (1159372-20-9,7039-50-1) → (2-amino-5-chlorophenyl)(phenyl)methanol (7039-50-1) + 5-chloro-2-aminobenzophenone (719-59-5)

Guidance literature:

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen; copper(II) bis(trifluoromethanesulfonate); (R)-1,1'-binaphthyl-2,2'-diamine; In toluene; at 80 ℃; for 11h; optical yield given as %ee;

DOI:10.1016/j.tetasy.2009.02.013

upstream raw materials:

benzaldehyde

4-chloro-aniline

5-chloro-2-aminobenzophenone

(5-chloro-2-nitro-phenyl)-phenyl-methanol

Downstream raw materials:

6-Chloro-2-ethylthio-3,4-diphenyl-3H-3,4-dihydroquinazoline hydroiodide

6-Chloro-2-ethylthio-4-phenyl-1H-3,4-dihydroquinazoline hydroiodide

6-Chloro-2-methylthio-4-phenyl-1H-3,4-dihydroquinazoline hydroiodide

6-chloro-4-phenyl-3,4-dihydro-1H-quinazolin-2-one

Refernces

• 1、 Yadav, Samanta,Vijayan, Paranthaman,Yadav, Sunil,Gupta, Rajeev. "Ruthenium complexes of phosphine-amide based ligands as efficient catalysts for transfer hydrogenation reactions". . p. 3269 - 3279. Retrieved 2021/03/16.
• 2、 Abaev, Vladimir T.,Plieva, Anastasiya T.,Chalikidi, Petrakis N.,Uchuskin, Maxim G.,Trushkov, Igor V.,Butin, Alexander V.. "A simple route to polysubstituted indoles exploiting azide induced furan ring opening". supporting information. p. 4150 - 4153. Retrieved 2014/09/30.