(2E,5S,6R,7S) 8-benzyloxy-6-(t-butyldimethylsilyloxy)-1-chloro-1,1-dideuterio-5,7-dimethyloct-2-ene

Base Information

Chemical Name:(2E,5S,6R,7S) 8-benzyloxy-6-(t-butyldimethylsilyloxy)-1-chloro-1,1-dideuterio-5,7-dimethyloct-2-ene
CAS No.:865302-09-6
Molecular Formula:C₂₃H₃₉ClO₂Si
Molecular Weight:413.084
Hs Code.:

Synonyms:(2E,5S,6R,7S) 8-benzyloxy-6-(t-butyldimethylsilyloxy)-1-chloro-1,1-dideuterio-5,7-dimethyloct-2-ene

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Chemical Property of (2E,5S,6R,7S) 8-benzyloxy-6-(t-butyldimethylsilyloxy)-1-chloro-1,1-dideuterio-5,7-dimethyloct-2-ene

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Technology Process of (2E,5S,6R,7S) 8-benzyloxy-6-(t-butyldimethylsilyloxy)-1-chloro-1,1-dideuterio-5,7-dimethyloct-2-ene

There total 3 articles about (2E,5S,6R,7S) 8-benzyloxy-6-(t-butyldimethylsilyloxy)-1-chloro-1,1-dideuterio-5,7-dimethyloct-2-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 164735-79-9
(2E,5S,6R,7S) 8-benzyloxy-6-(t-butyldimethylsilyloxy)-1,1-dideuterio-5,7-dimethyloct-2-en-1-ol

: 865302-09-6
(2E,5S,6R,7S) 8-benzyloxy-6-(t-butyldimethylsilyloxy)-1-chloro-1,1-dideuterio-5,7-dimethyloct-2-ene

Guidance literature:: With dmap; p-toluenesulfonyl chloride; In dichloromethane;
DOI:10.1016/S0040-4039(00)76541-5

Reference yield:

: 155299-98-2
(3S,4R,5S)-6-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethyl-hexanal

: 865302-09-6
(2E,5S,6R,7S) 8-benzyloxy-6-(t-butyldimethylsilyloxy)-1-chloro-1,1-dideuterio-5,7-dimethyloct-2-ene

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / LiCl, DIPEA / acetonitrile

2: 85 percent / DIBAL-D / tetrahydrofuran / -78 °C

3: 90 percent / TsCl, DMAP / CH₂Cl₂

With dmap; diisobutylaluminium deuteride; N-ethyl-N,N-diisopropylamine; p-toluenesulfonyl chloride; lithium chloride; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/S0040-4039(00)76541-5

Reference yield:

: 155299-99-3
(E)-(5S,6R,7S)-8-Benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-5,7-dimethyl-oct-2-enoic acid ethyl ester

: 865302-09-6
(2E,5S,6R,7S) 8-benzyloxy-6-(t-butyldimethylsilyloxy)-1-chloro-1,1-dideuterio-5,7-dimethyloct-2-ene

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / DIBAL-D / tetrahydrofuran / -78 °C

2: 90 percent / TsCl, DMAP / CH₂Cl₂

With dmap; diisobutylaluminium deuteride; p-toluenesulfonyl chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(00)76541-5