155299-99-3Relevant academic research and scientific papers
Synthesis of the acyltetronic acid ionophore tetronasin (ICI M139603)
Ley, Steven V.,Brown, Dearg S.,Clase, J. Andrew,Fairbanks, Antony J.,Lennon, Ian C.,Osborn, Helen M. I.,Stokes, Elaine S. E.,Wadsworth, David J.
, p. 2259 - 2276 (2007/10/03)
A synthetic strategy for the preparation of tetronasin 1, an acyltetronic acid ionophore demonstrating antibiotic, antiparasitic and growth promotion in ruminants is described. The key step involves a metal mediated cyclization reaction which creates two
Biosynthesis of Tetronasin: Part 4, Preparation of Deuterium Labelled C19-C26, C17-C26, C11-C26 and C3-C26 Polyketide Fragments as Putative Biosynthetic Precursors of the Ionophore Antibiotic Tetronasin (ICI 139603)
Boons, Geert-Jan,Clase, J. Andrew,Lennon, Ian C.,Ley, Steven V.,Staunton, James
, p. 5417 - 5446 (2007/10/02)
Six deuterium labelled N-acylcysteamine polyketide derivatives (3) - (8) have been prepared as putative precursors for incorporation in studies of the biosynthesis of the ionophore antibiotic tetronasin (1).The route to these compounds was designed to be
Two New Routes to the C19-C26 Tetrahydrofuran Fragment of the Acyl Tetronic Acid Ionophore Tetronasin (ICI M139603)
Boons, Geert-Jan,Brown, Dearg S.,Clase, J. Andrew,Lennon, Ian C.,Ley, Steven V.
, p. 319 - 322 (2007/10/02)
Two highly efficient and complementary synthetic routes to the C19-C26 tetrahydrofuran fragment (2) of the novel acyltetronic acid ionophore antibiotic tetronasin (ICI 139603) (1) are described to provide multigramme quantities of the required product.
Biosynthesis of Tetronasin: Part 3. Preparation of Deuterium Labelled Tri- and Tetraketides as Putative Biosynthetic Precursors of Tetronasin
Hailes, Helen C.,Handa, Sandeep,Leadlay, Peter F.,Lennon, Ian C.,Ley, Steven V.,Staunton, James
, p. 315 - 318 (2007/10/02)
The preparation of seven deuterium labelled N-acetyl cysteamine thioesters (2a), (2b), (3a), (3b), (4), (5) and (6) as putative biosynthetic precursors of the acyl tetronic acid ionophore tetronasin is described.
