4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-5-(4-nitrophenyl)pentanamide

Base Information

• Chemical Name: 4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-5-(4-nitrophenyl)pentanamide
• CAS No.: 119860-39-8
• Molecular Formula: C₁₉H₁₉F₂N₃O₆
• Molecular Weight: 423.373

Synonyms:4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-5-(4-nitrophenyl)pentanamide

Chemical Property of 4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-5-(4-nitrophenyl)pentanamide

Chemical Property:

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Technology Process of 4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-5-(4-nitrophenyl)pentanamide

There total 7 articles about 4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-5-(4-nitrophenyl)pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(S)-4-Benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-5-(4-nitro-phenyl)-pentanoic acid ethyl ester (119372-54-2,119372-55-3,119920-86-4,138875-60-2,138875-61-3) → [(S)-3-Carbamoyl-3,3-difluoro-2-hydroxy-1-(4-nitro-benzyl)-propyl]-carbamic acid benzyl ester (119351-64-3,119351-65-4,119860-39-8)

Guidance literature:

With ammonia; In diethyl ether; from -78 deg C to r.t.;

DOI:10.1016/S0040-4039(00)82154-1

Reference yield: 95.0%

(R,S)-4-benzyloxycarbonylamino-5-(4-nitrophenyl)-2,2-difluoro-3-hydroxypentanoic acid ethyl ester (119920-86-4) → 4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-5-(4-nitrophenyl)pentanamide (119860-39-8)

Guidance literature:

With ammonia; In diethyl ether; at -78 ℃;

DOI:10.1016/0040-4020(95)00896-G

Reference yield: 70.0%

→ 4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-5-(4-nitrophenyl)pentanamide (119860-39-8)

Guidance literature:

upstream raw materials:

(S)-4-Benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-5-(4-nitro-phenyl)-pentanoic acid ethyl ester

[(S)-1-Formyl-2-(4-nitro-phenyl)-ethyl]-carbamic acid benzyl ester

(S)-2-Benzyloxycarbonylamino-3-(4-nitro-phenyl)-propionic acid methyl ester

(R,S)-4-benzyloxycarbonylamino-5-(4-nitrophenyl)-2,2-difluoro-3-hydroxypentanoic acid ethyl ester

Downstream raw materials:

[(S)-4-Amino-3,3-difluoro-2-hydroxy-1-(4-nitro-benzyl)-butyl]-carbamic acid benzyl ester

[(S)-4-tert-Butoxycarbonylamino-3,3-difluoro-2-hydroxy-1-(4-nitro-benzyl)-butyl]-carbamic acid benzyl ester

[4-Amino-3,3-difluoro-2-hydroxy-1-(4-nitro-benzyl)-butyl]-carbamic acid benzyl ester

N⁴-benzyloxycarbonyl-N¹-tert-butoxycarbonyl-2,2-difluoro-3-hydroxy-5-(4-nitrophenyl)-1,4-pentanediamine

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