119920-86-4

Upstream product

• 20299-41-6 (S)-2-Benzyloxycarbonylamino-3-(4-nitro-phenyl)-propionic acid methyl ester 
• 142035-73-2 (R,S)-α-benzyloxycarbonylamino-3-(4-nitrophenyl)propionic acid methyl ester 
• 667-27-6 Ethyl bromodifluoroacetate 
• 119860-38-7 (R,S)-α-benzyloxycarbonylamino-3-(4-nitrophenyl)propanal 
• 119372-44-0 [(S)-1-Formyl-2-(4-nitro-phenyl)-ethyl]-carbamic acid benzyl ester 

Downstream Products

• 119860-39-8 4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-5-(4-nitrophenyl)pentanamide 
• 173918-66-6 C₅₂H₅₅F₂N₇O₁₀ 
• 138875-65-7 (S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid [4-acetylamino-3,3-difluoro-1-(4-guanidino-benzyl)-2-oxo-butyl]-amide; hydrochloride 
• 173918-66-6 (N-benzyloxycarbonyl-D-phenylalanyl)-N-<4-acetylamino-3,3-difluoro-2-hydroxy-1-<4((((benzyloxycarbonylamino)benzyloxycarbonylimino)methyl)amino)phenyl>methyl>butyl-L-prolinamide 
• 173918-65-5 (N-tert-butoxycarbonyl-D-phenylalanyl)-N-<4-acetylamino-1-<(4-tert-butoxycarbonylaminophenyl)methyl>-3,3-difluoro-2-hydroxybutyl>-L-prolinamide 
• 119860-11-6 N¹-acetyl-N⁴-benzyloxycarbonyl-2,2-difluoro-3-hydroxy-5(4-tert-butoxycarbonylamino-phenyl)-1,4-pentane diamine 
• 119860-08-1 N⁴-benzyloxycarbonyl-N¹-tert-butoxycarbonyl-2,2-difluoro-3-hydroxy-5-(4-nitrophenyl)-1,4-pentanediamine 
• 119860-10-5 N¹-acetyl-N⁴-benzyloxycarbonyl-2,2-difluoro-3-hydroxy-5-(4-nitrophenyl)-1,4-pentanediamine 
• 119885-17-5 N₁-Acetyl-N₄-benzyloxycarbonyl-2,2-difluoro-3-hydroxy-5-(4-aminophenyl)-1,4-pentanediamine 
• 119860-09-2 [4-Amino-3,3-difluoro-2-hydroxy-1-(4-nitro-benzyl)-butyl]-carbamic acid benzyl ester 
• 119860-12-7 [4-(5-Acetylamino-2-amino-4,4-difluoro-3-hydroxy-pentyl)-phenyl]-carbamic acid tert-butyl ester 
• 119351-74-5 [(S)-4-tert-Butoxycarbonylamino-3,3-difluoro-2-hydroxy-1-(4-nitro-benzyl)-butyl]-carbamic acid benzyl ester 
• 119860-09-2 [(S)-4-Amino-3,3-difluoro-2-hydroxy-1-(4-nitro-benzyl)-butyl]-carbamic acid benzyl ester 
• 119351-64-3 [(S)-3-Carbamoyl-3,3-difluoro-2-hydroxy-1-(4-nitro-benzyl)-propyl]-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Difluoromethyleneketone retroamide, a versatile concept of inactivation of proteolytic enzymes

The synthesis of difluoromethyleneketone retroamides is described. Several examples of application to aspartyl or seryl proteases illustrate the versatility of this inactivation concept. Copyright

General Synthesis of Polyfunctionalized Fluoromethyleneketone Retroamides as Potential Inhibitors of Thrombin

Synthesis of polyfunctionalized fluoromethyleneketone retroamides is described.A potential inhibitor of human Thrombin has been prepared through a Reformatsky type condensation from N-protected p-NO2 phenylalaninal.The reaction conditions are applicable t

Novel peptidase inhibitors

This invention relates to analogs of peptidase substrates in which the nitrogen atom of the scissile amide bond of a partial retropeptide analog of the substrate has been replaced by a difluoromethylene moiety. These peptidase substrate analogs provide specific enzyme inhibitors for a variety of proteases, the inhibition of which exert valuable pharmacological activities and therefore have useful physiological consequences in a variety of disease states.

A CONVENIENT SYNTHESIS OF &α',&β-DIAMINO- &α,&α-DIFLUOROKETONES, NEW DIPEPTIDE ISOSTERES

A convenient and versatile synthesis of α',β-diamino-α,α-difluoroketones is described.These compounds represent a new class of true dipeptide isosteres useful for the design of serine protease inhibitors.

Novel peptidase inhibitors

This invention relates to activated electrophilic ketone retroamide analogs of certain peptidase substrates having the formula R1NHCHR2COCF2CHR3(NRbCOXRa)nQ These compounds are useful in inhibiting serine-, thiol-, carboxylic acid- and metallo- dependent