H-PHE-NHNH2

Base Information

• Chemical Name: H-PHE-NHNH2
• CAS No.: 52386-52-4
• Molecular Formula: C₉H₁₃N₃O
• Molecular Weight: 179.222
• Hs Code.: 2928000090
• Mol file: 52386-52-4.mol

Synonyms:L-Alanine,phenyl-, hydrazide (6CI); NSC 251036

Chemical Property of H-PHE-NHNH2

Chemical Property:

• Vapor Pressure: 6.25E-07mmHg at 25°C
• Boiling Point: 410°Cat760mmHg
• PKA: 12.86±0.50(Predicted)
• Flash Point: 201.7°C
• PSA: 81.14000
• Density: 1.175g/cm³
• LogP: 1.33780
• Storage Temp.: Store at 0-5°C

Purity/Quality:

99% ^*data from raw suppliers

L-Phenylalanine hydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-PHE-NHNH2

There total 6 articles about H-PHE-NHNH2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) → 2-amino-3-phenylpropionic acid hydrazide (21820-50-8,52386-52-4,121475-84-1)

Guidance literature:

With hydrazine hydrate; In neat (no solvent); at 60 ℃; for 10h; Inert atmosphere;

DOI:10.1039/c9nj00022d

Reference yield: 80.0%

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) + hydrazine hydrate (7803-57-8,79785-97-0) → 2-amino-3-phenylpropionic acid hydrazide (21820-50-8,52386-52-4,121475-84-1)

Guidance literature:

In ethanol; water; at 20 ℃; for 24h;

DOI:10.1111/j.1747-0285.2011.01269.x

Reference yield:

methyl (2S)-2-amino-3-phenylpropanoate (2577-90-4) → 2-amino-3-phenylpropionic acid hydrazide (21820-50-8,52386-52-4,121475-84-1)

Guidance literature:

With hydrazine hydrate;

upstream raw materials:

methyl (2S)-2-amino-3-phenylpropanoate

DL-phenylalanine hydrazide

phenylalanine ethyl ester

L-phenylalanine

Downstream raw materials:

N'-[(2E/Z)-4-nitrobenzylidene]-(2S)-amino-3-phenylpropanehydrazide

1-[(1-ethoxyethylene)amino]-2-methyl-4-benzylimidazol-5(4H)-one

5-benzyl-3-methyl-1,4,5,6-tetrahydro-1,2,4-triazin-6(5H)-one

5-benzyl-3-ethyl-1,4,5,6-tetrahydro-1,2,4-triazin-6(5H)-one

Refernces

• 1、 Mondal, Milon,Radeva, Nedyalka,Fanlo-Virgós, Hugo,Otto, Sijbren,Klebe, Gerhard,Hirsch, Anna K. H.. "Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin: Fragment-Based Drug Design Facilitated by Dynamic Combinatorial Chemistry". supporting information. p. 9422 - 9426. Retrieved 2016/08/05.
• 2、 Kudelko, Agnieszka,Zieliński, Wojciech,Jasiak, Karolina. "Synthesis of novel 1-[(1-ethoxymethylene)amino]imidazol-5(4H)-ones and 1,2,4-triazin-6(5H)-ones from optically active α-aminocarboxylic acid hydrazides". . p. 4637 - 4640. Retrieved 2013/08/23.