7-methyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-oct-4-enoic acid tert-butyl ester

Base Information

• Chemical Name: 7-methyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-oct-4-enoic acid tert-butyl ester
• CAS No.: 221690-42-2
• Molecular Formula: C₃₂H₃₅NO₃
• Molecular Weight: 481.635

Synonyms:7-methyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-oct-4-enoic acid tert-butyl ester

Chemical Property of 7-methyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-oct-4-enoic acid tert-butyl ester

Chemical Property:

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Technology Process of 7-methyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-oct-4-enoic acid tert-butyl ester

There total 4 articles about 7-methyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-oct-4-enoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-hydroxy-7-methyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-octanoic acid tert-butyl ester (221690-27-3) → 7-methyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-oct-4-enoic acid tert-butyl ester (221690-42-2)

Guidance literature:

With methanesulfonyl chloride; triethylamine; In dichloromethane; 1.) 0 deg C, 30 min, 2.) room temp.;

DOI:10.1021/jo982181h

Reference yield:

3-methyl-butan-2-one (563-80-4) → 7-methyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-oct-4-enoic acid tert-butyl ester (221690-42-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / n-BuLi, diisopropylamine / tetrahydrofuran; hexane / -78 °C

2: 87 percent / CH₃SO₂Cl, Et₃N / CH₂Cl₂ / 1.) 0 deg C, 30 min, 2.) room temp.

With n-butyllithium; methanesulfonyl chloride; triethylamine; diisopropylamine; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/jo982181h

Reference yield:

N-(9-phenylfluoren-9-yl)-L-aspartic acid α-t-butyl β-methyl diester (120230-41-3) → 7-methyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-oct-4-enoic acid tert-butyl ester (221690-42-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / DIBAL-H / toluene / 0.42 h / -78 °C

2: 77 percent / n-BuLi, diisopropylamine / tetrahydrofuran; hexane / -78 °C

3: 87 percent / CH₃SO₂Cl, Et₃N / CH₂Cl₂ / 1.) 0 deg C, 30 min, 2.) room temp.

With n-butyllithium; diisobutylaluminium hydride; methanesulfonyl chloride; triethylamine; diisopropylamine; In tetrahydrofuran; hexane; dichloromethane; toluene;

DOI:10.1021/jo982181h

upstream raw materials:

4-hydroxy-7-methyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-octanoic acid tert-butyl ester

3-methyl-butan-2-one

N-(9-phenylfluoren-9-yl)-L-aspartic acid α-t-butyl β-methyl diester

tert-butyl (2S)-2-[(9-phenyl-9-fluorenyl)amino]-4-oxobutanoate

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