3-(1-benzyl-1H-tetrazol-5-yl)-4,4a,5,6,7,8a-hexahydropyrano[3,2-e][1,2]oxazine

Base Information

Chemical Name:3-(1-benzyl-1H-tetrazol-5-yl)-4,4a,5,6,7,8a-hexahydropyrano[3,2-e][1,2]oxazine
CAS No.:1343478-82-9
Molecular Formula:C₁₅H₁₇N₅O₂
Molecular Weight:299.332
Hs Code.:

Synonyms:3-(1-benzyl-1H-tetrazol-5-yl)-4,4a,5,6,7,8a-hexahydropyrano[3,2-e][1,2]oxazine

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Chemical Property of 3-(1-benzyl-1H-tetrazol-5-yl)-4,4a,5,6,7,8a-hexahydropyrano[3,2-e][1,2]oxazine

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Technology Process of 3-(1-benzyl-1H-tetrazol-5-yl)-4,4a,5,6,7,8a-hexahydropyrano[3,2-e][1,2]oxazine

There total 3 articles about 3-(1-benzyl-1H-tetrazol-5-yl)-4,4a,5,6,7,8a-hexahydropyrano[3,2-e][1,2]oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 1343478-79-4
1-(1-benzyl-1H-tetrazol-5-yl)-2-bromoethanone oxime

: 1343478-82-9
3-(1-benzyl-1H-tetrazol-5-yl)-4,4a,5,6,7,8a-hexahydropyrano[3,2-e][1,2]oxazine

: 1343478-83-0
1-(1-benzyl-1H-tetrazol-5-yl)-2-(3,4-dihydro-2H-pyran-5-yl)ethanone oxime

Guidance literature:: With sodium carbonate; In dichloromethane; at 20 ℃; for 70h; regioselective reaction;
DOI:10.1016/j.tet.2011.09.051

Reference yield:

: 1343478-77-2
1-(1-benzyl-1H-tetrazol-5-yl)-2-bromoethanone

: 1343478-82-9
3-(1-benzyl-1H-tetrazol-5-yl)-4,4a,5,6,7,8a-hexahydropyrano[3,2-e][1,2]oxazine

: 1343478-83-0
1-(1-benzyl-1H-tetrazol-5-yl)-2-(3,4-dihydro-2H-pyran-5-yl)ethanone oxime

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride / methanol; dichloromethane / 72 h / 20 °C

2: sodium carbonate / dichloromethane / 70 h / 20 °C

With hydroxylamine hydrochloride; sodium carbonate; In methanol; dichloromethane; 2: Diels-Alder reaction;
DOI:10.1016/j.tet.2011.09.051

Reference yield:

: 120869-86-5
5-acetyl-1-benzyl-1H-tetrazole

: 1343478-82-9
3-(1-benzyl-1H-tetrazol-5-yl)-4,4a,5,6,7,8a-hexahydropyrano[3,2-e][1,2]oxazine

: 1343478-83-0
1-(1-benzyl-1H-tetrazol-5-yl)-2-(3,4-dihydro-2H-pyran-5-yl)ethanone oxime

Guidance literature:: Multi-step reaction with 3 steps

1: 1,4-dioxane; bromine / diethyl ether / 19 h / 20 °C

2: hydroxylamine hydrochloride / methanol; dichloromethane / 72 h / 20 °C

3: sodium carbonate / dichloromethane / 70 h / 20 °C

With 1,4-dioxane; hydroxylamine hydrochloride; bromine; sodium carbonate; In methanol; diethyl ether; dichloromethane; 3: Diels-Alder reaction;
DOI:10.1016/j.tet.2011.09.051