5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine 3'-(N,N,N',N'-tetraisopropyl)phosphorodiamidite

Base Information

• Chemical Name: 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine 3'-(N,N,N',N'-tetraisopropyl)phosphorodiamidite
• CAS No.: 408512-17-4
• Molecular Formula: C₄₃H₅₉N₄O₈P
• Molecular Weight: 790.937
• Mol file: 408512-17-4.mol

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine 3'-(N,N,N',N'-tetraisopropyl)phosphorodiamidite

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine 3'-(N,N,N',N'-tetraisopropyl)phosphorodiamidite

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine 3'-(N,N,N',N'-tetraisopropyl)phosphorodiamidite

There total 1 articles about 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine 3'-(N,N,N',N'-tetraisopropyl)phosphorodiamidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

bis(diisopropylamino)chlorophosphine (56183-63-2) + 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine (103285-22-9) → 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine 3'-(N,N,N',N'-tetraisopropyl)phosphorodiamidite (408512-17-4)

Guidance literature:

With triethylamine; In 1,4-dioxane; at 20 ℃; for 2h;

DOI:10.1021/jo0002588

Reference yield: 43.0%

3'-O-acetyl-5-(2-hydroxypropyl)-2'-O-methyluridine (287101-04-6) + 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine 3'-(N,N,N',N'-tetraisopropyl)phosphorodiamidite (408512-17-4) → C46H51N4O16PS (305366-01-2)

Guidance literature:

3'-O-acetyl-5-(2-hydroxypropyl)-2'-O-methyluridine; 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine 3'-(N,N,N',N'-tetraisopropyl)phosphorodiamidite; With 1H-tetrazole; In 1,4-dioxane; carbon disulfide; acetonitrile; at 20 ℃; for 9h;

With sulfur; In acetonitrile; at 20 ℃; for 3h; Further stages.;

DOI:10.1021/jo0002588

Reference yield:

3'-O-acetyl-5-(2-hydroxypropyl)-2'-O-methyluridine (287101-04-6) + 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine 3'-(N,N,N',N'-tetraisopropyl)phosphorodiamidite (408512-17-4) → C46H51N4O16P

Guidance literature:

With 1H-tetrazole; In 1,4-dioxane; acetonitrile; at 20 ℃; for 5h;

DOI:10.1021/jo0002588

upstream raw materials:

bis(diisopropylamino)chlorophosphine

5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine

Downstream raw materials:

C₄₆H₅₁N₄O₁₆PS

C₄₆H₅₁N₄O₁₇P

Sp-DMTrUmpc₃Um

Rp-DMTrUmpc₃Um