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103285-22-9

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  • 1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxy-3-methoxyoxolan-2-yl]pyrimidine-2,4-dione cas no. 103285-22-9 98%

    Cas No: 103285-22-9

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103285-22-9 Usage

Chemical Properties

White to off white powder

Uses

5’-O-(Dimethoxytrityl)-2’-O-methyluridine is a potential therapeutic agent. Also, it is a reagent used in the synthesis of 2’-modified-4’-thioRNA.

Check Digit Verification of cas no

The CAS Registry Mumber 103285-22-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,2,8 and 5 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 103285-22:
(8*1)+(7*0)+(6*3)+(5*2)+(4*8)+(3*5)+(2*2)+(1*2)=89
89 % 10 = 9
So 103285-22-9 is a valid CAS Registry Number.

103285-22-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxy-3-methoxyoxolan-2-yl]pyrimidine-2,4-dione

1.2 Other means of identification

Product number -
Other names DMT-2'-OMe-U

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:103285-22-9 SDS

103285-22-9Relevant articles and documents

Boronic acid-based autoligation of nucleic acids: Influence of the nature of the 3′-end ribonucleotidic strand

Barbeyron, Renaud,Wengel, Jesper,Vasseur, Jean-Jacques,Smietana, Michael

, p. 495 - 500 (2013)

The development of synthetic systems displaying dynamic and adaptive characteristics is a formidable challenge with wide applications from biotechnology to therapeutics. Recently, we described a dynamic and programmable nucleic acid-based system relying on the formation of reversible boronate internucleosidic linkages. The DNA- or RNA-templated system comprises a 5′-ended boronic acid probe connecting a 3′-ended ribonucleosidic oligonucleotide partner. To explore the dominant factors that control the reversible linkage, we synthesized a series of 3′-end modified ribonucleotidic strands. Evidence suggests that geometric and steric factors are key features for controlling the equilibria.

Synthesis and anti-HCV activity of 3′,4′-oxetane nucleosides

Chang, Wonsuk,Du, Jinfa,Rachakonda, Suguna,Ross, Bruce S.,Convers-Reignier, Serge,Yau, Wei T.,Pons, Jean-Francois,Murakami, Eisuke,Bao, Haiying,Steuer, Holly Micolochick,Furman, Phillip A.,Otto, Michael J.,Sofia, Michael J.

scheme or table, p. 4539 - 4543 (2010/11/03)

Hepatitis C virus afflicts approximately 180 million people worldwide and currently there are no direct acting antiviral agents available to treat this disease. Our first generation nucleoside HCV inhibitor, RG7128 has already established proof-of-concept

Process for the preparation of 2'-O-alkyl purine phosphoramidites

-

, (2016/06/29)

2'-O-alkylated guanosine, uridine, cytidine, and 2,6-diaminopurine 3'-O-phosphoramidites are prepared by alkylating nucleoside precursors, adding suitable blocking groups and phosphitylating. Alkylation is effected on 2,6-diamino-9-(β-D-ribofuranosyl)purine followed by deamination to prepare guanosine 2'-O-alkylated 3'-O-phosphormidites. Alkylation is effected on a dialkyl stannylene derivative of uridine to prepare uridine 2'-O-alkylated 3'-O-phosphormidites. Alkylation is effected directly on cytidine to prepare cytidine 2'-O-alkylated 3'-O-phosphormidites. Alkylation is effected directly on 2,6-diaminopurine to prepare 2,6-diaminopurine 2'-O-alkylated 3'-O-phosphormidites.

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