(2S,5R,6R)-6-amino-2-(benzyloxycarbonyl)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane p-toluenesulfonic acid

Base Information

Chemical Name:(2S,5R,6R)-6-amino-2-(benzyloxycarbonyl)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane p-toluenesulfonic acid
CAS No.:19912-14-2
Molecular Formula:C₇H₈O₃S*C₁₅H₁₈N₂O₃S
Molecular Weight:478.59
Hs Code.:

Synonyms:(2S,5R,6R)-6-amino-2-(benzyloxycarbonyl)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane p-toluenesulfonic acid

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Chemical Property of (2S,5R,6R)-6-amino-2-(benzyloxycarbonyl)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane p-toluenesulfonic acid

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Technology Process of (2S,5R,6R)-6-amino-2-(benzyloxycarbonyl)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane p-toluenesulfonic acid

There total 5 articles about (2S,5R,6R)-6-amino-2-(benzyloxycarbonyl)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane p-toluenesulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: benzyl (2S,5R,6R)-6-(((Z)ethylcrotonate-2-yl)amino)-3,3-dimethyl-7-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

: 104-15-4
toluene-4-sulfonic acid

: 19912-14-2
(2S,5R,6R)-6-amino-2-(benzyloxycarbonyl)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane p-toluenesulfonic acid

Guidance literature:: In acetone; for 0.166667h; Time;

Reference yield: 72.0%

: 87106-44-3
(2S,5R,6R)-6-((Z)-2-Methoxycarbonyl-1-methyl-vinylamino)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyl ester

: 104-15-4
toluene-4-sulfonic acid

: 19912-14-2
(2S,5R,6R)-6-amino-2-(benzyloxycarbonyl)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane p-toluenesulfonic acid

Guidance literature:: In acetone; for 0.166667h; Ambient temperature;
DOI:10.1055/s-1983-30419

Reference yield:

: 551-16-6
6-Aminopenicillanic Acid

: 19912-14-2
(2S,5R,6R)-6-amino-2-(benzyloxycarbonyl)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane p-toluenesulfonic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) N(C₂H₅)3 / 1.) CH₂Cl₂, room temp., 2.) 3 h, room temp.

2: 70 percent / dimethylformamide / 3 h

3: 72 percent / acetone / 0.17 h / Ambient temperature

With triethylamine; In N,N-dimethyl-formamide; acetone;
DOI:10.1055/s-1983-30419