(E)-3-(5-benzyloxycarbonyl-3-methylthiophen-2-yl)-2-propenoic acid tert-butyl ester

Base Information

Chemical Name:(E)-3-(5-benzyloxycarbonyl-3-methylthiophen-2-yl)-2-propenoic acid tert-butyl ester
CAS No.:1311291-36-7
Molecular Formula:C₂₀H₂₂O₄S
Molecular Weight:358.458
Hs Code.:

Synonyms:(E)-3-(5-benzyloxycarbonyl-3-methylthiophen-2-yl)-2-propenoic acid tert-butyl ester

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Chemical Property of (E)-3-(5-benzyloxycarbonyl-3-methylthiophen-2-yl)-2-propenoic acid tert-butyl ester

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Technology Process of (E)-3-(5-benzyloxycarbonyl-3-methylthiophen-2-yl)-2-propenoic acid tert-butyl ester

There total 3 articles about (E)-3-(5-benzyloxycarbonyl-3-methylthiophen-2-yl)-2-propenoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 27784-76-5
tert-butyl diethylphosphonoacetate

: 1311291-35-6
5-formyl-4-methylthiophene-2-carboxylic acid benzyl ester

: 1311291-36-7
(E)-3-(5-benzyloxycarbonyl-3-methylthiophen-2-yl)-2-propenoic acid tert-butyl ester

Guidance literature:: tert-butyl diethylphosphonoacetate; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

5-formyl-4-methylthiophene-2-carboxylic acid benzyl ester; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

Reference yield:

: 391936-73-5
1,3-dimethyl-2-(3'-methyl-2'-thienyl)imidazolidine

: 1311291-36-7
(E)-3-(5-benzyloxycarbonyl-3-methylthiophen-2-yl)-2-propenoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

1.2: 1 h / 20 °C

2.1: potassium carbonate / 3 h / 60 °C

3.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C

3.2: 2 h / 0 - 20 °C

With n-butyllithium; sodium hydride; potassium carbonate; In tetrahydrofuran; hexane;

Reference yield:

: 5834-16-2,699531-50-5
3-methyl-2-thiophenecarboxaldehdye

: 1311291-36-7
(E)-3-(5-benzyloxycarbonyl-3-methylthiophen-2-yl)-2-propenoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 120 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

2.2: 1 h / 20 °C

3.1: potassium carbonate / 3 h / 60 °C

4.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C

4.2: 2 h / 0 - 20 °C

With n-butyllithium; sodium hydride; potassium carbonate; In tetrahydrofuran; hexane; toluene;