Technology Process of 1-benzyl 3-(tert-butyl) (1S,3R)-2,2-dimethylcyclobutane-1,3-dicarboxylate
There total 4 articles about 1-benzyl 3-(tert-butyl) (1S,3R)-2,2-dimethylcyclobutane-1,3-dicarboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tetrabutylammomium bromide; sodium carbonate;
In
dichloromethane; water;
at 0 - 20 ℃;
for 12h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 20 °C / Cooling with ice
2: sodium hydroxide; water; bromine / 13 h / 0 - 20 °C
3: sodium carbonate; tetrabutylammomium bromide / dichloromethane; water / 12 h / 0 - 20 °C
With
dmap; tetrabutylammomium bromide; water; bromine; sodium carbonate; dicyclohexyl-carbodiimide; sodium hydroxide;
In
dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: water; potassium permanganate / acetone / 3 h / 0 °C
2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 20 °C / Cooling with ice
3: sodium hydroxide; water; bromine / 13 h / 0 - 20 °C
4: sodium carbonate; tetrabutylammomium bromide / dichloromethane; water / 12 h / 0 - 20 °C
With
dmap; potassium permanganate; tetrabutylammomium bromide; water; bromine; sodium carbonate; dicyclohexyl-carbodiimide; sodium hydroxide;
In
dichloromethane; water; acetone;
