phenyl 3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenylcarbamate

Base Information

Chemical Name:phenyl 3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenylcarbamate
CAS No.:1449763-30-7
Molecular Formula:C₃₀H₃₀FN₃O₆
Molecular Weight:547.583
Hs Code.:

Synonyms:phenyl 3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenylcarbamate

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Chemical Property of phenyl 3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenylcarbamate

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Technology Process of phenyl 3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenylcarbamate

There total 9 articles about phenyl 3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.2%

: 479690-10-3
3-Fluoro-4-{[6-methoxy-7-(3-morpholinopropoxy)-4-quinolyl]oxy}-aniline

: 1885-14-9
phenyl chloroformate

: 1449763-30-7
phenyl 3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenylcarbamate

Guidance literature:: With potassium carbonate; In acetone; at 0 - 20 ℃; for 3h;
DOI:10.1016/j.bmc.2013.06.026

Reference yield:

: 58113-30-7
4-(3-chloropropoxy)-3-methoxyacetophenone

: 1449763-30-7
phenyl 3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenylcarbamate

Guidance literature:: Multi-step reaction with 8 steps

1: nitric acid / dichloromethane / 2 h / -10 °C

2: toluene / 110 °C

3: iron / acetic acid / 2 h / 40 - 80 °C

4: acetonitrile / 8 h / 25 - 80 °C

5: trichlorophosphate / acetonitrile / 6 h / Reflux

6: chlorobenzene / 20 h / 140 °C

7: iron; hydrogenchloride / ethanol; water / 2 h / Reflux

8: potassium carbonate / acetone / 3 h / 0 - 20 °C

With hydrogenchloride; nitric acid; iron; potassium carbonate; trichlorophosphate; In ethanol; dichloromethane; water; acetic acid; chlorobenzene; acetone; toluene; acetonitrile;
DOI:10.1016/j.bmc.2013.06.026

Reference yield:

: 1167053-13-5,205448-38-0
6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-ol, sodium salt

: 1449763-30-7
phenyl 3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / acetonitrile / 6 h / Reflux

2: chlorobenzene / 20 h / 140 °C

3: iron; hydrogenchloride / ethanol; water / 2 h / Reflux

4: potassium carbonate / acetone / 3 h / 0 - 20 °C

With hydrogenchloride; iron; potassium carbonate; trichlorophosphate; In ethanol; water; chlorobenzene; acetone; acetonitrile;
DOI:10.1016/j.bmc.2013.06.026