4-hydroxy-2-oxo-1-phenyl-1,2-dihydroquinoline-3-carboxylicacid methyl ester

Base Information

• Chemical Name: 4-hydroxy-2-oxo-1-phenyl-1,2-dihydroquinoline-3-carboxylicacid methyl ester
• CAS No.: 770711-44-9
• Molecular Formula: C₁₇H₁₃NO₄
• Molecular Weight: 295.295

Synonyms:4-hydroxy-2-oxo-1-phenyl-1,2-dihydroquinoline-3-carboxylicacid methyl ester

Chemical Property of 4-hydroxy-2-oxo-1-phenyl-1,2-dihydroquinoline-3-carboxylicacid methyl ester

Chemical Property:

Purity/Quality:

95+% ^*data from raw suppliers

Methyl4-hydroxy-2-oxo-1-phenyl-1,2-dihydroquinoline-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-hydroxy-2-oxo-1-phenyl-1,2-dihydroquinoline-3-carboxylicacid methyl ester

There total 6 articles about 4-hydroxy-2-oxo-1-phenyl-1,2-dihydroquinoline-3-carboxylicacid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

malonic acid dimethyl ester (108-59-8) + 2-phenylamino-benzoic acid benzotriazol-1-yl ester → 4-hydroxy-2-oxo-1-phenyl-1,2-dihydroquinoline-3-carboxylicacid methyl ester (770711-44-9)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃; for 2.5h;

DOI:10.1246/bcsj.77.1505

Reference yield:

2-(phenylamino)benzoic acid (91-40-7) + malonic acid dimethyl ester (108-59-8) → 4-hydroxy-2-oxo-1-phenyl-1,2-dihydroquinoline-3-carboxylicacid methyl ester (770711-44-9)

Guidance literature:

2-(phenylamino)benzoic acid; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran;

malonic acid dimethyl ester; With sodium hydride; In tetrahydrofuran; Further stages.;

DOI:10.1021/jm061173n

Reference yield:

2-(phenylamino)benzoic acid (91-40-7) → 4-hydroxy-2-oxo-1-phenyl-1,2-dihydroquinoline-3-carboxylicacid methyl ester (770711-44-9)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N'-dicyclohexylcarbodiimide / tetrahydrofuran / 3 - 5 °C

2: 2.1 g / NaH / tetrahydrofuran / 2.5 h / 20 °C

With sodium hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran;

DOI:10.1246/bcsj.77.1505

upstream raw materials:

malonic acid dimethyl ester

2-(phenylamino)benzoic acid

N-phenyl isatoic anhydride

ortho-chlorobenzoic acid

Downstream raw materials:

C₁₈H₁₇N₃O₃

C₂₂H₁₇N₃O₃

N-[2-(dimethylamino)ethyl]-4-hydroxy-2-oxo-1-phenyl-1,2-dihydroquinoline-3-carboxamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 770711-44-9 4-hydroxy-2-oxo-1-phenyl-1,2-dihydroquinoline-3-carboxylicacid methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send