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Technology Process of C15H19ClINO3

C15H19ClINO3

Base Information
  • Chemical Name:C15H19ClINO3
  • CAS No.:1335387-17-1
  • Molecular Formula:C15H19ClINO3
  • Molecular Weight:423.678
  • Hs Code.:
C<sub>15</sub>H<sub>19</sub>ClINO<sub>3</sub>

Synonyms:C15H19ClINO3

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Chemical Property of C15H19ClINO3
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Technology Process of C15H19ClINO3

There total 5 articles about C15H19ClINO3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C<sub>9</sub>H<sub>9</sub>ClINO

C9H9ClINO

C<sub>15</sub>H<sub>19</sub>ClINO<sub>3</sub>
1335387-17-1

C15H19ClINO3

Guidance literature:
Multi-step reaction with 3 steps
1: sodium hydrogencarbonate / tetrahydrofuran
2: N,N-diisopropylamido-magnesium bromide; magnesium chloride / tetrahydrofuran
3: hydrogenchloride / water
With hydrogenchloride; N,N-diisopropylamido-magnesium bromide; sodium hydrogencarbonate; magnesium chloride; In tetrahydrofuran; water;
DOI:10.1016/j.bmcl.2012.01.037

Reference yield:

C<sub>16</sub>H<sub>19</sub>INO<sub>5</sub><sup>(1-)</sup>*Na<sup>(1+)</sup>

C16H19INO5(1-)*Na(1+)

C<sub>15</sub>H<sub>19</sub>ClINO<sub>3</sub>
1335387-17-1

C15H19ClINO3

Guidance literature:
With hydrogenchloride; In water;
DOI:10.1016/j.bmcl.2012.01.037

Reference yield:

L-phenylalanine
63-91-2,25191-15-5,658-69-5,67675-33-6

L-phenylalanine

C<sub>15</sub>H<sub>19</sub>ClINO<sub>3</sub>
1335387-17-1

C15H19ClINO3

Guidance literature:
Multi-step reaction with 5 steps
1: sodium iodate; sulfuric acid; iodine; acetic acid
2: thionyl chloride / methanol / Reflux
3: sodium hydrogencarbonate / tetrahydrofuran
4: N,N-diisopropylamido-magnesium bromide; magnesium chloride / tetrahydrofuran
5: hydrogenchloride / water
With hydrogenchloride; thionyl chloride; sodium iodate; sulfuric acid; N,N-diisopropylamido-magnesium bromide; iodine; sodium hydrogencarbonate; acetic acid; magnesium chloride; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.bmcl.2012.01.037
upstream raw materials:

L-phenylalanine

4-iodo-L-phenylalanine

N-(tert-butoxycarbonyl)-4-iodo-L-phenylalanine methyl ester

Downstream raw materials:

methyl 4'-((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-2-(((((S)-tetrahydrofuran-3-yl)oxy)carbonyl)amino)butyl)-[1,1'-biphenyl]-3-carboxylate

(S)-tetrahydrofuran-3-yl ((2S,3R)-3-hydroxy-1-(3'-hydroxy-[1,1'-biphenyl]-4-yl)-4-(N-isobutyl-4-methoxyphenylsulfonamido)butan-2-yl)carbamate

4'-((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-2-(((((S)-tetrahydrofuran-3-yl)oxy)carbonyl)amino)butyl)-[1,1'-biphenyl]-4-carboxylic acid

(S)-tetrahydrofuran-3-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)1-(4'-methoxy-3'-methyl-[1,1'-biphenyl]-4-yl)butan-2-yl)carbamate

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