1-[2-(4-bromo-2-methyl-phenylamino)-ethyl]-4-(tert-butyl-diphenyl-silanyloxy)-cyclohexanecarboxylic acid ethyl ester

Base Information

Chemical Name:1-[2-(4-bromo-2-methyl-phenylamino)-ethyl]-4-(tert-butyl-diphenyl-silanyloxy)-cyclohexanecarboxylic acid ethyl ester
CAS No.:1350375-48-2
Molecular Formula:C₃₄H₄₄BrNO₃Si
Molecular Weight:622.718
Hs Code.:

Synonyms:1-[2-(4-bromo-2-methyl-phenylamino)-ethyl]-4-(tert-butyl-diphenyl-silanyloxy)-cyclohexanecarboxylic acid ethyl ester

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Chemical Property of 1-[2-(4-bromo-2-methyl-phenylamino)-ethyl]-4-(tert-butyl-diphenyl-silanyloxy)-cyclohexanecarboxylic acid ethyl ester

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Technology Process of 1-[2-(4-bromo-2-methyl-phenylamino)-ethyl]-4-(tert-butyl-diphenyl-silanyloxy)-cyclohexanecarboxylic acid ethyl ester

There total 5 articles about 1-[2-(4-bromo-2-methyl-phenylamino)-ethyl]-4-(tert-butyl-diphenyl-silanyloxy)-cyclohexanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1350375-37-9
4-(tert-butyl-diphenyl-silanyloxy)-1-(2-oxo-ethyl)-cyclohexanecarboxylic acidmethyl ester

: 583-75-5
4-Bromo-2-methylaniline

: 1350375-48-2
1-[2-(4-bromo-2-methyl-phenylamino)-ethyl]-4-(tert-butyl-diphenyl-silanyloxy)-cyclohexanecarboxylic acid ethyl ester

Guidance literature:: 4-(tert-butyl-diphenyl-silanyloxy)-1-(2-oxo-ethyl)-cyclohexanecarboxylic acidmethyl ester; 4-Bromo-2-methylaniline; acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 2h;

With ammonium hydroxide; water; In dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1350375-48-2
1-[2-(4-bromo-2-methyl-phenylamino)-ethyl]-4-(tert-butyl-diphenyl-silanyloxy)-cyclohexanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / dichloromethane / 20 °C

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

2.2: 1.33 h / -78 - 20 °C

3.1: osmium(VIII) oxide; sodium periodate; water / isopropyl alcohol / 16 h / 20 °C

4.1: acetic acid / 1,2-dichloro-ethane / 1 h / 20 °C

4.2: 2 h / 20 °C

With 1H-imidazole; sodium periodate; osmium(VIII) oxide; n-butyllithium; water; diisopropylamine; acetic acid; In tetrahydrofuran; hexane; dichloromethane; 1,2-dichloro-ethane; isopropyl alcohol;

Reference yield:

: 3618-04-0,75877-66-6,17159-80-7
4-hydroxycyclohexyl carboxylic acid ethyl ester

: 1350375-48-2
1-[2-(4-bromo-2-methyl-phenylamino)-ethyl]-4-(tert-butyl-diphenyl-silanyloxy)-cyclohexanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / dichloromethane / 20 °C

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

2.2: 1.33 h / -78 - 20 °C

3.1: osmium(VIII) oxide; sodium periodate; water / isopropyl alcohol / 16 h / 20 °C

4.1: acetic acid / 1,2-dichloro-ethane / 1 h / 20 °C

4.2: 2 h / 20 °C

With 1H-imidazole; sodium periodate; osmium(VIII) oxide; n-butyllithium; water; diisopropylamine; acetic acid; In tetrahydrofuran; hexane; dichloromethane; 1,2-dichloro-ethane; isopropyl alcohol;