(1R,3R)-2,2-Dimethyl-3-[(R)-1-((R)-toluene-4-sulfinyl)-2-trimethylsilanyl-ethyl]-cyclopropanecarboxylic acid ethyl ester

Base Information

• Chemical Name: (1R,3R)-2,2-Dimethyl-3-[(R)-1-((R)-toluene-4-sulfinyl)-2-trimethylsilanyl-ethyl]-cyclopropanecarboxylic acid ethyl ester
• CAS No.: 191422-45-4
• Molecular Formula: C₂₀H₃₂O₃SSi
• Molecular Weight: 380.624
• Mol file: 191422-45-4.mol

Synonyms:(1R,3R)-2,2-Dimethyl-3-[(R)-1-((R)-toluene-4-sulfinyl)-2-trimethylsilanyl-ethyl]-cyclopropanecarboxylic acid ethyl ester

Chemical Property of (1R,3R)-2,2-Dimethyl-3-[(R)-1-((R)-toluene-4-sulfinyl)-2-trimethylsilanyl-ethyl]-cyclopropanecarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,3R)-2,2-Dimethyl-3-[(R)-1-((R)-toluene-4-sulfinyl)-2-trimethylsilanyl-ethyl]-cyclopropanecarboxylic acid ethyl ester

There total 3 articles about (1R,3R)-2,2-Dimethyl-3-[(R)-1-((R)-toluene-4-sulfinyl)-2-trimethylsilanyl-ethyl]-cyclopropanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(RS)-p-Tolyl β-(trimethylsilyl)ethyl sulfoxide (153123-09-2) + Ethyl 4-chloro-4-methylpent-2-enoate → (1R,3R)-2,2-Dimethyl-3-[(R)-1-((R)-toluene-4-sulfinyl)-2-trimethylsilanyl-ethyl]-cyclopropanecarboxylic acid ethyl ester (191422-45-4)

Guidance literature:

(R_S)-p-Tolyl β-(trimethylsilyl)ethyl sulfoxide; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.0833333h;

Ethyl 4-chloro-4-methylpent-2-enoate; In tetrahydrofuran; at -78 ℃; for 0.25h;

DOI:10.1039/a908649h

Reference yield: 79.0%

ethyl 4-bromo-4-methyl-penten-2-oate (77953-92-5) + (RS)-p-Tolyl β-(trimethylsilyl)ethyl sulfoxide (153123-09-2) → (1R,3R)-2,2-Dimethyl-3-[(R)-1-((R)-toluene-4-sulfinyl)-2-trimethylsilanyl-ethyl]-cyclopropanecarboxylic acid ethyl ester (191422-45-4)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.25h;

DOI:10.1055/s-1997-6144

Reference yield: 79.0%

ethyl 4-bromo-4-methyl-penten-2-oate (77953-92-5) + (RS)-p-Tolyl β-(trimethylsilyl)ethyl sulfoxide (153123-09-2) → (1R,3R)-2,2-Dimethyl-3-[(R)-1-((R)-toluene-4-sulfinyl)-2-trimethylsilanyl-ethyl]-cyclopropanecarboxylic acid ethyl ester (191422-45-4) + [2-Bromo-2-((S)-toluene-4-sulfinyl)-ethyl]-trimethyl-silane

Guidance literature:

(R_S)-p-Tolyl β-(trimethylsilyl)ethyl sulfoxide; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.0833333h;

ethyl 4-bromo-4-methyl-penten-2-oate; In tetrahydrofuran; at -78 ℃; for 0.25h;

DOI:10.1039/a908649h

upstream raw materials:

ethyl 4-bromo-4-methyl-penten-2-oate

(R_S)-p-Tolyl β-(trimethylsilyl)ethyl sulfoxide