1-tert-Butylamino-3-[3,5-dichloro-4-(imidazolidin-2-ylideneamino)-phenoxy]-propan-2-ol

Base Information

Chemical Name:1-tert-Butylamino-3-[3,5-dichloro-4-(imidazolidin-2-ylideneamino)-phenoxy]-propan-2-ol
CAS No.:120215-56-7
Molecular Formula:C₁₆H₂₄Cl₂N₄O₂
Molecular Weight:375.298
Hs Code.:

Synonyms:1-tert-Butylamino-3-[3,5-dichloro-4-(imidazolidin-2-ylideneamino)-phenoxy]-propan-2-ol

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Chemical Property of 1-tert-Butylamino-3-[3,5-dichloro-4-(imidazolidin-2-ylideneamino)-phenoxy]-propan-2-ol

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Technology Process of 1-tert-Butylamino-3-[3,5-dichloro-4-(imidazolidin-2-ylideneamino)-phenoxy]-propan-2-ol

There total 5 articles about 1-tert-Butylamino-3-[3,5-dichloro-4-(imidazolidin-2-ylideneamino)-phenoxy]-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 120215-59-0
2-<<2,6-dichloro-4-<3-(tert-butylamino)-2-hydroxypropoxy>phenyl>imino>-1,3-diacetylimidazolidine

: 120215-56-7
1-tert-Butylamino-3-[3,5-dichloro-4-(imidazolidin-2-ylideneamino)-phenoxy]-propan-2-ol

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; for 6h; Heating;
DOI:10.1021/jm00115a008

Reference yield:

: 57101-48-1
p-hydroxyclonidine

: 120215-56-7
1-tert-Butylamino-3-[3,5-dichloro-4-(imidazolidin-2-ylideneamino)-phenoxy]-propan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 63 percent / Heating

2: 79 percent / NaBH₄, LiCl / bis-(2-methoxy-ethyl) ether / 18 h / 50 °C

3: 1.) NaH / 1.) DMF, 2 h, 2.) DMF, RT, 24 h

4: ethanol / 24 h

5: 77 percent / 0.5 N aq. NaOH / tetrahydrofuran / 6 h / Heating

With sodium hydroxide; sodium tetrahydroborate; sodium hydride; lithium chloride; In tetrahydrofuran; ethanol; diethylene glycol dimethyl ether;
DOI:10.1021/jm00115a008

Reference yield:

: 109988-71-8
2-<(4-hydroxy-2,6-dichlorophenyl)imino>-1,3-diacetylimidazolidine

: 120215-56-7
1-tert-Butylamino-3-[3,5-dichloro-4-(imidazolidin-2-ylideneamino)-phenoxy]-propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 2 h, 2.) DMF, RT, 24 h

2: ethanol / 24 h

3: 77 percent / 0.5 N aq. NaOH / tetrahydrofuran / 6 h / Heating

With sodium hydroxide; sodium hydride; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00115a008