(S)-methyl 4-[2-{6-isopropyl-2-oxo-3-phenyltetrahydropyrimidin-1(2H)-yl}-2-oxoethoxy]-3,5-dimethoxybenzoate

Base Information

Chemical Name:(S)-methyl 4-[2-{6-isopropyl-2-oxo-3-phenyltetrahydropyrimidin-1(2H)-yl}-2-oxoethoxy]-3,5-dimethoxybenzoate
CAS No.:1404575-39-8
Molecular Formula:C₂₅H₃₀N₂O₇
Molecular Weight:470.522
Hs Code.:

Synonyms:(S)-methyl 4-[2-{6-isopropyl-2-oxo-3-phenyltetrahydropyrimidin-1(2H)-yl}-2-oxoethoxy]-3,5-dimethoxybenzoate

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Chemical Property of (S)-methyl 4-[2-{6-isopropyl-2-oxo-3-phenyltetrahydropyrimidin-1(2H)-yl}-2-oxoethoxy]-3,5-dimethoxybenzoate

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Technology Process of (S)-methyl 4-[2-{6-isopropyl-2-oxo-3-phenyltetrahydropyrimidin-1(2H)-yl}-2-oxoethoxy]-3,5-dimethoxybenzoate

There total 9 articles about (S)-methyl 4-[2-{6-isopropyl-2-oxo-3-phenyltetrahydropyrimidin-1(2H)-yl}-2-oxoethoxy]-3,5-dimethoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1404575-38-7
C₁₂H₁₃ClO₆

: 1404573-75-6
(S)-4-isopropyl-1-phenyltetrahydropyrimidin-2(1H)-one

: 1404575-39-8
(S)-methyl 4-[2-{6-isopropyl-2-oxo-3-phenyltetrahydropyrimidin-1(2H)-yl}-2-oxoethoxy]-3,5-dimethoxybenzoate

Guidance literature:: (S)-4-isopropyl-1-phenyltetrahydropyrimidin-2(1H)-one; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

C₁₂H₁₃ClO₆; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 2h;
DOI:10.1021/ol302653g

Reference yield:

: 1404575-37-6
2-[2,6-dimethoxy-4-(methoxycarbonyl)phenoxy]acetic acid

: 1404575-39-8
(S)-methyl 4-[2-{6-isopropyl-2-oxo-3-phenyltetrahydropyrimidin-1(2H)-yl}-2-oxoethoxy]-3,5-dimethoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

2.2: 2 h / -78 - 0 °C

With n-butyllithium; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ol302653g

Reference yield:

: 1404573-71-2
(S)-4-methyl-N¹-phenylpentane-1,3-diamine

: 1404575-39-8
(S)-methyl 4-[2-{6-isopropyl-2-oxo-3-phenyltetrahydropyrimidin-1(2H)-yl}-2-oxoethoxy]-3,5-dimethoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / water; toluene / 1 h / 0 °C / Inert atmosphere

1.2: 1 h / 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

2.2: 2 h / -78 - 0 °C

With n-butyllithium; potassium carbonate; In tetrahydrofuran; hexane; water; toluene;
DOI:10.1021/ol302653g