methyl 4-((1S,2S)-1-(4-(benzyloxy)-3-methoxyphenyl)-1,3-dihydroxypropan-2-yloxy)-3,5-dimethoxybenzoate

Base Information

Chemical Name:methyl 4-((1S,2S)-1-(4-(benzyloxy)-3-methoxyphenyl)-1,3-dihydroxypropan-2-yloxy)-3,5-dimethoxybenzoate
CAS No.:1404575-41-2
Molecular Formula:C₂₇H₃₀O₉
Molecular Weight:498.53
Hs Code.:

Synonyms:methyl 4-((1S,2S)-1-(4-(benzyloxy)-3-methoxyphenyl)-1,3-dihydroxypropan-2-yloxy)-3,5-dimethoxybenzoate

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Chemical Property of methyl 4-((1S,2S)-1-(4-(benzyloxy)-3-methoxyphenyl)-1,3-dihydroxypropan-2-yloxy)-3,5-dimethoxybenzoate

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Technology Process of methyl 4-((1S,2S)-1-(4-(benzyloxy)-3-methoxyphenyl)-1,3-dihydroxypropan-2-yloxy)-3,5-dimethoxybenzoate

There total 8 articles about methyl 4-((1S,2S)-1-(4-(benzyloxy)-3-methoxyphenyl)-1,3-dihydroxypropan-2-yloxy)-3,5-dimethoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1404575-40-1
methyl 4-((1S,2R)-1-(4-(benzyloxy)-3-methoxyphenyl)-1-hydroxy-3-((S)-6-isopropyl-2-oxo-3-phenyltetrahydropyrimidin-1(2H)-yl)-3-oxopropan-2-yloxy)-3,5-dimethoxybenzoate

: 1404575-41-2
methyl 4-((1S,2S)-1-(4-(benzyloxy)-3-methoxyphenyl)-1,3-dihydroxypropan-2-yloxy)-3,5-dimethoxybenzoate

: 1404573-75-6
(S)-4-isopropyl-1-phenyltetrahydropyrimidin-2(1H)-one

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; water; at 20 ℃; for 10h;
DOI:10.1021/ol302653g

Reference yield:

: 2426-87-1
3-methoxy-4-(phenylmethoxy)benzaldehyde

: 1404575-41-2
methyl 4-((1S,2S)-1-(4-(benzyloxy)-3-methoxyphenyl)-1,3-dihydroxypropan-2-yloxy)-3,5-dimethoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: titanium tetrachloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / -78 - 0 °C

1.2: 1 h / -78 °C

2.1: sodium tetrahydroborate / tetrahydrofuran; water / 10 h / 20 °C

With sodium tetrahydroborate; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ol302653g

Reference yield:

: 1404575-37-6
2-[2,6-dimethoxy-4-(methoxycarbonyl)phenoxy]acetic acid

: 1404575-41-2
methyl 4-((1S,2S)-1-(4-(benzyloxy)-3-methoxyphenyl)-1,3-dihydroxypropan-2-yloxy)-3,5-dimethoxybenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

2.2: 2 h / -78 - 0 °C

3.1: titanium tetrachloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / -78 - 0 °C

3.2: 1 h / -78 °C

4.1: sodium tetrahydroborate / tetrahydrofuran; water / 10 h / 20 °C

With sodium tetrahydroborate; n-butyllithium; oxalyl dichloride; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; hexane; dichloromethane; water;
DOI:10.1021/ol302653g