Z-L-p-Fluoro-Phe-chloromethylketone

Base Information

• Chemical Name: Z-L-p-Fluoro-Phe-chloromethylketone
• CAS No.: 400771-48-4
• Molecular Formula: C18H17ClFNO3
• Molecular Weight: 349.78400
• DSSTox Substance ID: DTXSID60427234
• Wikidata: Q82239933
• Mol file: 400771-48-4.mol

Synonyms:Z-L-p-Fluoro-Phe-chloromethylketone;400771-48-4;Z-4-fluoro-L-phenylalanine chloromethylketone;BENZYL N-[(2S)-4-CHLORO-1-(4-FLUOROPHENYL)-3-OXOBUTAN-2-YL]CARBAMATE;SCHEMBL6489247;DTXSID60427234;SSXSAFSLNOWRIX-INIZCTEOSA-N;BDBM512556;acs.jmedchem.1c00409_ST.149;(3S)-3-Benzyloxycarbonylamino-1-chloro-4-(p-fluorophenyl)-2-butanone;MFCD00238488;A6695;CS-0452145;(R)-benzyl 4-chloro-1-(4-fluorophenyl)-3-oxobutan-2-ylcarbamate;Benzyl (S)-(4-chloro-1-(4-fluorophenyl)-3-oxobutan-2-yl)carbamate;benzyl [(1s)-3-chloro-1-(4-fluorobenzyl)-2-oxopropyl]carbamate;(3S)-3-Benzyloxycarbonylamino-1-chloro4-(p-fluorophenyl)-2-butanone

Chemical Property of Z-L-p-Fluoro-Phe-chloromethylketone

Chemical Property:

• PSA: 58.89000
• LogP: 3.67550
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 8
• Exact Mass: 349.0880993
• Heavy Atom Count: 24
• Complexity: 407

Purity/Quality:

97% ^*data from raw suppliers

Z-4-fluoro-L-phenylalanine chloromethylketone ≥ 99% (TLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC(=O)NC(CC2=CC=C(C=C2)F)C(=O)CCl
• Isomeric SMILES: C1=CC=C(C=C1)COC(=O)N[C@@H](CC2=CC=C(C=C2)F)C(=O)CCl

Technology Process of Z-L-p-Fluoro-Phe-chloromethylketone

There total 1 articles about Z-L-p-Fluoro-Phe-chloromethylketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (3S)-3-benzyloxycarbonylamino-1-chloro-4-(p-fluorophenyl)-2-butanone (400771-48-4)

Guidance literature:

Reference yield:

(3S)-3-benzyloxycarbonylamino-1-chloro-4-(p-fluorophenyl)-2-butanone (400771-48-4) → (2S,3S)-1-chloro-2-hydroxy-3-(N-benzyloxycarbonylamino)-4-(p-fluorophenyl)butane (439807-30-4) + (2R,3S)-1-chloro-2-hydroxy-3-(N-benzyloxycarbonylamino)-4-(p-fluorophenyl)butane

Guidance literature:

With formic acid; triethylamine; (C₅Me₅)(Cl)Rh((1R,2R)-N-p-tosyl-1,2-diphenylethylenediamine); In ethyl acetate; at 25 ℃; for 2h;

DOI:10.1021/jo0491455

Reference yield:

chloro(pentamethylcyclopentadienyl)rhodium (III) (1R,2R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine + (3S)-3-benzyloxycarbonylamino-1-chloro-4-(p-fluorophenyl)-2-butanone (400771-48-4) → (2R,3S)-1-chloro-2-hydroxy-3-(N-benzyloxycarbonylamino)-4-(p-fluorophenyl)butane

Guidance literature:

In ethyl acetate;

Downstream raw materials:

(2S,3S)-1-chloro-2-hydroxy-3-(N-benzyloxycarbonylamino)-4-(p-fluorophenyl)butane

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 400771-48-4 Z-L-p-Fluoro-Phe-chloromethylketone

Send

Send

Metric Ton KG G Pound L ML

Send

Send