Diacetyl-L-Glycerophosphorylcholine

Base Information

• Chemical Name: Diacetyl-L-Glycerophosphorylcholine
• CAS No.: 54672-38-7
• Molecular Formula: C12H24 N O8 P
• Molecular Weight: 341.298
• Hs Code.: 2923900090
• Mol file: 54672-38-7.mol

Synonyms:3,5,9-Trioxa-4-phosphaundecan-1-aminium,7-(acetyloxy)-4-hydroxy-N,N,N-trimethyl-10-oxo-, inner salt, 4-oxide, (R)-

Chemical Property of Diacetyl-L-Glycerophosphorylcholine

Chemical Property:

• PSA: 121.00000
• LogP: 0.75920

Purity/Quality:

99%, ^*data from raw suppliers

DIACETYL-L-GLYCEROPHOSPHORYLCHOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Diacetyl-L-Glycerophosphorylcholine

There total 3 articles about Diacetyl-L-Glycerophosphorylcholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

choline tosylate (55357-38-5) + (S)-1,2-O-Diacetylglycerol (127179-48-0) → (R)-1,2-diacetoxy glycerylphosphoryl choline (54672-38-7,144861-12-1)

Guidance literature:

(S)-1,2-O-Diacetylglycerol; With triethylamine; trichlorophosphate; In dichloromethane; at 0 ℃; for 0.833333h;

choline tosylate; With pyridine; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

With water; In dichloromethane; for 1h;

DOI:10.5012/bkcs.2010.31.9.2689

Reference yield:

sodium methylate (124-41-4) + lecithin (6931-84-6,70094-88-1,128114-92-1,17708-90-6,159701-21-0) → (R)-1,2-diacetoxy glycerylphosphoryl choline (54672-38-7,144861-12-1)

Guidance literature:

lecithin; With soybean lipoxygenase-1; tris-(2-carboxyethyl)-phosphine hydrochloride; In ethanol; at 20 ℃; for 0.5h; pH=9; Inert atmosphere; Enzymatic reaction;

sodium methylate; In methanol; at 20 ℃; for 0.166667h;

DOI:10.1016/j.abb.2019.108082

Reference yield:

acetic anhydride (108-24-7) + L-glycero-3-phosphorylcholine (28319-77-9,563-24-6) → (R)-1,2-diacetoxy glycerylphosphoryl choline (54672-38-7,144861-12-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; at 55 ℃;

DOI:10.1021/acs.oprd.6b00261

upstream raw materials:

choline tosylate

(S)-1,2-O-Diacetylglycerol

acetic anhydride

L-glycero-3-phosphorylcholine

Downstream raw materials:

L-glycero-3-phosphorylcholine

Refernces

• 1、 Subramaniam, Rajesh,Jagadeesan, Ramesh,Mathew, Iswarya,Cen, Yana,Balaz, Stefan. "Scalable Synthesis and Purification of Acetylated Phosphatidyl Choline Headgroup". . p. 177 - 181. Retrieved 2017/02/26.