(9-{(2R,3S,4R,5R)-3-Fluoro-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-[(4-methoxy-phenyl)-diphenyl-methyl]-amine

Base Information

Chemical Name:(9-{(2R,3S,4R,5R)-3-Fluoro-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-[(4-methoxy-phenyl)-diphenyl-methyl]-amine
CAS No.:667456-03-3
Molecular Formula:C₇₀H₆₀FN₅O₆
Molecular Weight:1086.27
Hs Code.:

(9-{(2R,3S,4R,5R)-3-Fluoro-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-[(4-methoxy-phenyl)-diphenyl-methyl]-amine

Synonyms:(9-{(2R,3S,4R,5R)-3-Fluoro-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-[(4-methoxy-phenyl)-diphenyl-methyl]-amine

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Chemical Property of (9-{(2R,3S,4R,5R)-3-Fluoro-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-[(4-methoxy-phenyl)-diphenyl-methyl]-amine

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Technology Process of (9-{(2R,3S,4R,5R)-3-Fluoro-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-[(4-methoxy-phenyl)-diphenyl-methyl]-amine

There total 4 articles about (9-{(2R,3S,4R,5R)-3-Fluoro-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-[(4-methoxy-phenyl)-diphenyl-methyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 667455-99-4
Trifluoro-methanesulfonic acid (2R,3R,4R,5R)-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-tetrahydro-furan-3-yl ester

: 667456-03-3
(9-{(2R,3S,4R,5R)-3-Fluoro-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-[(4-methoxy-phenyl)-diphenyl-methyl]-amine

Guidance literature:: With tetrabutyl ammonium fluoride; In acetonitrile; at 72 - 74 ℃; for 0.5h;
DOI:10.1002/jlcr.712

Reference yield:

: 14470-28-1
mono-4-methoxytrityl chloride

: 667456-03-3
(9-{(2R,3S,4R,5R)-3-Fluoro-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-[(4-methoxy-phenyl)-diphenyl-methyl]-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 28 percent / dimethylaminopyridine; pyridine / 18 h / 85 - 88 °C

2: 90 percent / pyridine / 0.67 h / 0 - 20 °C

3: 20 percent / n-Bu₄NF / acetonitrile / 0.5 h / 72 - 74 °C

With pyridine; dmap; tetrabutyl ammonium fluoride; In acetonitrile;
DOI:10.1002/jlcr.712

Reference yield:

: 58-61-7
adenosine

: 667456-03-3
(9-{(2R,3S,4R,5R)-3-Fluoro-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-[(4-methoxy-phenyl)-diphenyl-methyl]-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 28 percent / dimethylaminopyridine; pyridine / 18 h / 85 - 88 °C

2: 90 percent / pyridine / 0.67 h / 0 - 20 °C

3: 20 percent / n-Bu₄NF / acetonitrile / 0.5 h / 72 - 74 °C

With pyridine; dmap; tetrabutyl ammonium fluoride; In acetonitrile;
DOI:10.1002/jlcr.712