5-MALEIMIDO VALERIC ACID

Base Information

• Chemical Name: 5-MALEIMIDO VALERIC ACID
• CAS No.: 57078-99-6
• Molecular Formula: C9H11 N O4
• Molecular Weight: 197.191
• Hs Code.: 2925190090
• Mol file: 57078-99-6.mol

Synonyms:5-Maleimidopentanoicacid; N-(4-Carboxybutyl)maleimide

Chemical Property of 5-MALEIMIDO VALERIC ACID

Chemical Property:

• PSA: 74.68000
• LogP: 0.10420
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%Min ^*data from raw suppliers

5-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)pentanoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: 5-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)pentanoic acid contains a maleimide group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
• Uses: 5-Maleimidopentanoic Acid is a potential inhibitor of prostaglandin endoperoxide synthase (PGHS)?.

Technology Process of 5-MALEIMIDO VALERIC ACID

There total 7 articles about 5-MALEIMIDO VALERIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C13H19NO4 → 5-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)pentanoic acid (57078-99-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; at 4 - 20 ℃; for 0.5h;

Reference yield: 90.0%

5-(3’,6’-endoxo-Δ-tetrahydrophthalimido)pentanoic acid → 5-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)pentanoic acid (57078-99-6)

Guidance literature:

In N,N-dimethyl-formamide; toluene; for 6h; Reflux;

Reference yield: 60.0%

maleic anhydride (108-31-6) + 5-aminopentanoic acid (660-88-8) → 5-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)pentanoic acid (57078-99-6)

Guidance literature:

In acetic acid; for 1.5h; Heating;

DOI:10.1055/s-2008-1032016

upstream raw materials:

maleic anhydride

5-aminopentanoic acid

tert-butyl 2-hydroxyethylpropionate

Downstream raw materials:

2,5-dioxopyrrolidin-1-yl 5-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)pentanoate

Refernces

• 1、 -. "Conjugate of cytotoxin molecule and cell binding receptor molecule". Paragraph 0032; 0302-0304. . Retrieved 2019/10/10.
• 2、 -. "Conjugates of Cell Binding Molecules with Cytotoxic Agents". . . Retrieved 2017/11/06.