1-benzyl 2-cyclopentyl 4-(4-{3-[(1-isobutoxyethoxy)amino]-3-oxopropyl}benzyl)piperazine-1,2-dicarboxylate

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Chemical Name:1-benzyl 2-cyclopentyl 4-(4-{3-[(1-isobutoxyethoxy)amino]-3-oxopropyl}benzyl)piperazine-1,2-dicarboxylate
CAS No.:1018674-57-1
Molecular Formula:C₃₄H₄₇N₃O₇
Molecular Weight:609.763
Hs Code.:

Synonyms:1-benzyl 2-cyclopentyl 4-(4-{3-[(1-isobutoxyethoxy)amino]-3-oxopropyl}benzyl)piperazine-1,2-dicarboxylate

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Chemical Property of 1-benzyl 2-cyclopentyl 4-(4-{3-[(1-isobutoxyethoxy)amino]-3-oxopropyl}benzyl)piperazine-1,2-dicarboxylate

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Technology Process of 1-benzyl 2-cyclopentyl 4-(4-{3-[(1-isobutoxyethoxy)amino]-3-oxopropyl}benzyl)piperazine-1,2-dicarboxylate

There total 6 articles about 1-benzyl 2-cyclopentyl 4-(4-{3-[(1-isobutoxyethoxy)amino]-3-oxopropyl}benzyl)piperazine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 860216-27-9
O-(1-isobutoxyethyl)hydroxylamine

: 1018674-56-0
3-[4-({4-[(benzyloxy)carbonyl]-3-[(cyclopentyloxy)carbonyl]piperazin-1-yl}methyl)phenyl]propanoic acid

: 1018674-57-1
1-benzyl 2-cyclopentyl 4-(4-{3-[(1-isobutoxyethoxy)amino]-3-oxopropyl}benzyl)piperazine-1,2-dicarboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 - 50 ℃; for 21h;

Reference yield:

: 619-66-9
4-Carboxybenzaldehyde

: 1018674-57-1
1-benzyl 2-cyclopentyl 4-(4-{3-[(1-isobutoxyethoxy)amino]-3-oxopropyl}benzyl)piperazine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / water / 1.5 h / 0 - 20 °C

1.2: pH 1 / Acidic aqueous solution

2.1: borane-THF / tetrahydrofuran / 2 h / 0 - 20 °C

3.1: sodium hydroxide; hydrogen / palladium diacetate / water / 4.5 h

4.1: lithium hydroxide / methanol; water / 18 h / 20 °C

4.2: pH 3

5.1: manganese(IV) oxide / dichloromethane / 18 h / 35 °C

6.1: sodium tris(acetoxy)borohydride; triethylamine / 1,2-dichloro-ethane / 18 h / 20 °C

7.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 21 h / 20 - 50 °C

With manganese(IV) oxide; lithium hydroxide; sodium hydroxide; borane-THF; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium diacetate; In tetrahydrofuran; methanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 115974-97-5
methyl (E)-4-carboxyl cinnamate

: 1018674-57-1
1-benzyl 2-cyclopentyl 4-(4-{3-[(1-isobutoxyethoxy)amino]-3-oxopropyl}benzyl)piperazine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: borane-THF / tetrahydrofuran / 2 h / 0 - 20 °C

2.1: sodium hydroxide; hydrogen / palladium diacetate / water / 4.5 h

3.1: lithium hydroxide / methanol; water / 18 h / 20 °C

3.2: pH 3

4.1: manganese(IV) oxide / dichloromethane / 18 h / 35 °C

5.1: sodium tris(acetoxy)borohydride; triethylamine / 1,2-dichloro-ethane / 18 h / 20 °C

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 21 h / 20 - 50 °C

With manganese(IV) oxide; lithium hydroxide; sodium hydroxide; borane-THF; hydrogen; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium diacetate; In tetrahydrofuran; methanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;