(-)-(8S)-2-{(E)-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]vinyl}-8-(2-trifluoromethylphenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine-(2S,3S)-2,3-bis[(2,2-dimethylpropanoyl)oxy]succinic acid

Base Information

• Chemical Name: (-)-(8S)-2-{(E)-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]vinyl}-8-(2-trifluoromethylphenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine-(2S,3S)-2,3-bis[(2,2-dimethylpropanoyl)oxy]succinic acid
• CAS No.: 1213771-62-0
• Molecular Formula: C₁₄H₂₂O₈*C₂₅H₂₃F₃N₆O
• Molecular Weight: 798.816
• Mol file: 1213771-62-0.mol

Synonyms:(-)-(8S)-2-{(E)-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]vinyl}-8-(2-trifluoromethylphenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine-(2S,3S)-2,3-bis[(2,2-dimethylpropanoyl)oxy]succinic acid

Chemical Property of (-)-(8S)-2-{(E)-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]vinyl}-8-(2-trifluoromethylphenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine-(2S,3S)-2,3-bis[(2,2-dimethylpropanoyl)oxy]succinic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-(8S)-2-{(E)-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]vinyl}-8-(2-trifluoromethylphenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine-(2S,3S)-2,3-bis[(2,2-dimethylpropanoyl)oxy]succinic acid

There total 6 articles about (-)-(8S)-2-{(E)-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]vinyl}-8-(2-trifluoromethylphenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine-(2S,3S)-2,3-bis[(2,2-dimethylpropanoyl)oxy]succinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.4%

(S,E,E)-2-(2-(6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl)vinyl)-8-(2-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine (1123193-82-7) + dipivaloyl-(-)-tartaric acid (76769-55-6) → (-)-(8S)-2-{(E)-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]vinyl}-8-(2-trifluoromethylphenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine-(2S,3S)-2,3-bis[(2,2-dimethylpropanoyl)oxy]succinic acid (1213771-62-0)

Guidance literature:

In isopropyl alcohol; for 2.5h;

Reference yield: 43.7%

(-)-2-{(E)-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]vinyl}-8-(2-trifluoromethylphenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine (1123193-86-1) + dipivaloyl-(-)-tartaric acid (76769-55-6) → (-)-(8S)-2-{(E)-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]vinyl}-8-(2-trifluoromethylphenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine-(2S,3S)-2,3-bis[(2,2-dimethylpropanoyl)oxy]succinic acid (1213771-62-0)

Guidance literature:

In isopropyl alcohol; acetonitrile; at 10 - 50 ℃;

Reference yield:

5-chloro-2-(2-trifluoromethylphenyl)pentanimidic acid ethyl ester hydrochloride (1123197-78-3) → (-)-(8S)-2-{(E)-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]vinyl}-8-(2-trifluoromethylphenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine-(2S,3S)-2,3-bis[(2,2-dimethylpropanoyl)oxy]succinic acid (1213771-62-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium acetate / methanol / 25 h / 10 - 15 °C / Inert atmosphere; Large scale

1.2: 60 h / 40 - 45 °C / Large scale

2.1: methanol; ethyl acetate / 7 h / 8 - 53 °C / Inert atmosphere; Large scale

With sodium acetate; In methanol; ethyl acetate;

DOI:10.1021/acs.oprd.8b00444

upstream raw materials:

(S,E,E)-2-(2-(6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl)vinyl)-8-(2-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine

dipivaloyl-(-)-tartaric acid

(-)-2-{(E)-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]vinyl}-8-(2-trifluoromethylphenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine

5-chloro-2-(2-trifluoromethylphenyl)pentanimidic acid ethyl ester hydrochloride

Downstream raw materials:

(S,E,E)-2-(2-(6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl)vinyl)-8-(2-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine