N-(methoxymethyl)-3-indolecarboxaldehyde

Base Information

• Chemical Name: N-(methoxymethyl)-3-indolecarboxaldehyde
• CAS No.: 73540-77-9
• Molecular Formula: C₁₁H₁₁NO₂
• Molecular Weight: 189.214
• Mol file: 73540-77-9.mol

Synonyms:(1-methoxymethyl-indol-3-yl)carboxaldehyde

Chemical Property of N-(methoxymethyl)-3-indolecarboxaldehyde

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

1-(methoxymethyl)-1H-Indole-3-carboxaldehyde 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(methoxymethyl)-3-indolecarboxaldehyde

There total 3 articles about N-(methoxymethyl)-3-indolecarboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

Indole-3-carboxaldehyde (487-89-8,1228547-52-1) + chloromethyl methyl ether (107-30-2) → (1-methoxymethyl-indol-3-yl)carboxaldehyde (73540-77-9)

Guidance literature:

Indole-3-carboxaldehyde; With sodium hydride; In tetrahydrofuran; at -5 - 20 ℃;

chloromethyl methyl ether; With ammonium hydroxide; In tetrahydrofuran; at 20 ℃; for 0.5h;

Reference yield: 87.0%

1-(methoxymethyl)-1H-indole (40899-68-1) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → (1-methoxymethyl-indol-3-yl)carboxaldehyde (73540-77-9)

Guidance literature:

1-(methoxymethyl)-1H-indole; With trichlorophosphate;

N,N-dimethyl-formamide; at 0 ℃;

DOI:10.1021/om901031m

Reference yield: 86.0%

Indole-3-carboxaldehyde (487-89-8,1228547-52-1) + bromethyl methyl ether (13057-17-5) → (1-methoxymethyl-indol-3-yl)carboxaldehyde (73540-77-9)

Guidance literature:

Indole-3-carboxaldehyde; bromethyl methyl ether; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1.25h; Inert atmosphere;

In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1021/jacs.1c09889

upstream raw materials:

Indole-3-carboxaldehyde

chloromethyl methyl ether

1-(methoxymethyl)-1H-indole

N,N-dimethyl-formamide

Downstream raw materials:

5H-pyrido[4,3-b]carbazole-5,11(6H)-dione

ellipticine

9-Methoxymethyl-1-(2-nitro-benzoyl)-9H-β-carboline-3-carboxylic acid ethyl ester

1-(2-Chloro-benzoyl)-9-methoxymethyl-9H-β-carboline-3-carboxylic acid ethyl ester