(2R,3S)-ethyl N-((R)-tert-butylsulfinyl)-3-hydroxy-3-(4-nitrophenyl)-2-phenylpropanimidate

Base Information

Chemical Name:(2R,3S)-ethyl N-((R)-tert-butylsulfinyl)-3-hydroxy-3-(4-nitrophenyl)-2-phenylpropanimidate
CAS No.:1582230-05-4
Molecular Formula:C₂₁H₂₆N₂O₅S
Molecular Weight:418.514
Hs Code.:

Synonyms:(2R,3S)-ethyl N-((R)-tert-butylsulfinyl)-3-hydroxy-3-(4-nitrophenyl)-2-phenylpropanimidate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S)-ethyl N-((R)-tert-butylsulfinyl)-3-hydroxy-3-(4-nitrophenyl)-2-phenylpropanimidate

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Technology Process of (2R,3S)-ethyl N-((R)-tert-butylsulfinyl)-3-hydroxy-3-(4-nitrophenyl)-2-phenylpropanimidate

There total 2 articles about (2R,3S)-ethyl N-((R)-tert-butylsulfinyl)-3-hydroxy-3-(4-nitrophenyl)-2-phenylpropanimidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1582229-82-0
(R)-ethyl N-tert-butylsulfinyl-2-phenylacetimidate

: 555-16-8
4-nitrobenzaldehdye

: 1582230-05-4
(2R,3S)-ethyl N-((R)-tert-butylsulfinyl)-3-hydroxy-3-(4-nitrophenyl)-2-phenylpropanimidate

Guidance literature:: With titanium(IV) dichlorodiisopropylate; triethylamine; In dichloromethane; at 20 ℃; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol500520h

Reference yield:

: 16754-56-6
(2,2,2-triethoxyethyl)benzene

: 1582230-05-4
(2R,3S)-ethyl N-((R)-tert-butylsulfinyl)-3-hydroxy-3-(4-nitrophenyl)-2-phenylpropanimidate

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / neat (no solvent) / 18 h / 100 °C

2: triethylamine; titanium(IV) dichlorodiisopropylate / dichloromethane / 20 °C / Inert atmosphere

With titanium(IV) dichlorodiisopropylate; toluene-4-sulfonic acid; triethylamine; In dichloromethane;
DOI:10.1021/ol500520h