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Usage

Uses

Used in Chemical Processes:
2,2,2-Triethoxyethylbenzene is used as a solvent for its ability to dissolve a wide range of substances, facilitating various chemical reactions and processes.
Used in Organic Synthesis:
It serves as an intermediate in the synthesis of other organic compounds, contributing to the formation of complex molecular structures.
Used as a Reagent:
2,2,2-Triethoxyethylbenzene is utilized as a reagent in organic reactions, particularly for the formation of carbon-carbon and carbon-nitrogen bonds, which are crucial in creating new chemical entities.
Used in Pharmaceutical Manufacturing:
It is employed in the production of pharmaceuticals due to its capacity to participate in the synthesis of medicinal compounds, enhancing the development of new drugs.
Used in Agrochemical Production:
2,2,2-Triethoxyethylbenzene is used in the manufacturing of agrochemicals, where its reactivity aids in the creation of substances that can protect crops and enhance agricultural productivity.
Used in Specialty Chemicals:
Its versatile properties and reactivity make 2,2,2-Triethoxyethylbenzene suitable for use in the production of specialty chemicals, catering to specific industrial needs.

Upstream product

• 64-17-5 ethanol 
• 13049-42-8 phenylketene diethylacetal 
• 140-29-4 phenylacetonitrile 
• 4369-00-0 (2,2,2-trimethoxyethyl)benzene 
• 5442-34-2 ethyl 2-phenylacetimidate hydrochloride 

Downstream Products

• 75-00-3 chloroethane 
• 122-79-2 Phenyl acetate 
• 100834-60-4 2-benzyl-1,3-bis-(3-methyl-benzothiazol-2-yl)-trimethinium ; iodide 
• 15775-44-7 2-(1-Ethoxy-phenethyliden)-cyclopent-4-en-1,3-dion 
• 3468-99-3 ethyl diphenylacetate 
• 101-97-3 Ethyl 2-phenylethanoate 
• 1327166-05-1 ethyl 2-phenyl-N-tosylacetimidate 
• 68557-20-0 5-amino-3-benzyl-1-phenyl[1,2,4]triazole 
• 1582229-82-0 (R)-ethyl N-tert-butylsulfinyl-2-phenylacetimidate 
• 1582230-34-9 (2R,3S)-ethyl N-((R)-tert-butylsulfinyl)-3-hydroxy-4,4-dimethyl-2-phenyl-propanimidate 
• 1582230-05-4 (2R,3S)-ethyl N-((R)-tert-butylsulfinyl)-3-hydroxy-3-(4-nitrophenyl)-2-phenylpropanimidate 
• 1582230-00-9 (2R,3S)-ethyl N-((R)-tert-butylsulfinyl)-3-hydroxy-3-(3-methoxyphenyl)-2-phenylpropanimidate 
• 1582229-90-0 (2R,3S)-ethyl N-((R)-tert-butylsulfinyl)-3-hydroxy-2,3-diphenylpropanimidate 
• 621-72-7 2-benzylbenzimidazole 

Relevant academic research and scientific papers

Self-assembled orthoester cryptands: Orthoester scope, post-functionalization, kinetic locking and tunable degradation kinetics

Dynamic adaptability and biodegradability are key features of functional, 21st century host-guest systems. We have recently discovered a class of tripodal supramolecular hosts, in which two orthoesters act as constitutionally dynamic bridgeheads. Having previously demonstrated the adaptive nature of these hosts, we now report the synthesis and characterization-including eight solid state structures-of a diverse set of orthoester cages, which provides evidence for the broad scope of this new host class. With the same set of compounds, we demonstrated that the rates of orthoester exchange and hydrolysis can be tuned over a remarkably wide range, from rapid hydrolysis at pH 8 to nearly inert at pH 1, and that the Taft parameter of the orthoester substituent allows an adequate prediction of the reaction kinetics. Moreover, the synthesis of an alkyne-capped cryptand enabled the post-functionalization of orthoester cryptands by Sonogashira and CuAAC "click" reactions. The methylation of the resulting triazole furnished a cryptate that was kinetically inert towards orthoester exchange and hydrolysis at pH > 1, which is equivalent to the "turnoff" of constitutionally dynamic imines by means of reduction. These findings indicate that orthoester cages may be more broadly useful than anticipated, e.g. as drug delivery agents with precisely tunable biodegradability or, thanks to the kinetic locking strategy, as ion sensors.

EPOTHILONE ANALOGUES MODIFIED AT POSITIONS C12-C13 AS ANTICANCER DRUGS

The invention relates to analogues of epothilones of formulae (A), (B), (I) and (II), uses and methods of making the same.

8-Amino-3-benzyl-1,2,4-triazolopyrazines. Synthesis and Anticonvulsant Activity

Eleven substituted 8-amino-3-benzyl-1,2,4-triazolopyrazines were synthesized and tested for anticonvulsant activity against maximal electroshock-induced seizures (MES) in rats.The compounds were prepared in four stages from the phenylacetonitriles