(1H-indazol-3-yl)methanol

Base Information

• Chemical Name: (1H-indazol-3-yl)methanol
• CAS No.: 64132-13-4
• Molecular Formula: C8H8N2O
• Molecular Weight: 148.164
• Hs Code.: 2933990090
• European Community (EC) Number: 814-280-4
• DSSTox Substance ID: DTXSID40363641
• Wikidata: Q82147374
• Mol file: 64132-13-4.mol

Synonyms:(1H-indazol-3-yl)methanol;64132-13-4;1H-Indazole-3-methanol;1H-indazol-3-ylmethanol;3-(Hydroxymethyl)indazole;2H-indazol-3-ylmethanol;(1H-indazol-3-yl)-methanol;3-(HYDROXYMETHYL)-1H-INDAZOLE;SCHEMBL960630;DTXSID40363641;MFCD05260509;STK666033;AKOS003396209;GS-4115;PB26152;AC-25003;A8803;AM20040942;CS-0052546;FT-0604109;EN300-317080;J-500181

Chemical Property of (1H-indazol-3-yl)methanol

Chemical Property:

• Vapor Pressure: 0.0535mmHg at 25°C
• Melting Point: 138-139 °C
• Refractive Index: 1.721
• Boiling Point: 223.9 °C at 760 mmHg
• PKA: 13.56±0.10(Predicted)
• Flash Point: 89.2 °C
• PSA: 48.91000
• Density: 1.36 g/cm³
• LogP: 1.05520
• Storage Temp.: 2-8°C
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 148.063662883
• Heavy Atom Count: 11
• Complexity: 140

Purity/Quality:

97% ^*data from raw suppliers

(1H-Indazol-3-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(NN=C2C=C1)CO

Technology Process of (1H-indazol-3-yl)methanol

There total 7 articles about (1H-indazol-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(1-tosyl-1H-indazol-3-yl)methanol → 3-(hydroxymethyl)-1H-indazole (64132-13-4)

Guidance literature:

With magnesium; In methanol; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/adsc.201500953

Reference yield: 87.0%

methyl 1H-indazole-3-carboxylate (43120-28-1) → 3-(hydroxymethyl)-1H-indazole (64132-13-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃;

Reference yield: 77.0%

1H-Indazole-3-carboxylic acid (4498-67-3) → 3-(hydroxymethyl)-1H-indazole (64132-13-4)

Guidance literature:

1H-Indazole-3-carboxylic acid; With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; toluene; at 0 ℃; for 4h; Heating / reflux;

With sodium hydroxide; water; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 0.25h;

upstream raw materials:

methyl 1H-indazole-3-carboxylate

1H-Indazole-3-carboxylic acid

2-bromophenyl methyl ketone

α-hydroxy-2-bromoacetophenone

Downstream raw materials:

tert-butyl 3-(hydroxymethyl)-1H-indazole-1-carboxylate

tert-butyl 3-formyl-1H-indazole-1-carboxylate

1H-indazole-3-carboxaldehyde

(3-hydroxymethyl-indazol-1-yl)-m-tolylmethanone