1-(2,4-dihydroxy-benzenesulfonyl)-3-phenyl-5-[1-pyridin-2-ymethylidene]-piperidin-4-one

Base Information

Chemical Name:1-(2,4-dihydroxy-benzenesulfonyl)-3-phenyl-5-[1-pyridin-2-ymethylidene]-piperidin-4-one
CAS No.:1096167-32-6
Molecular Formula:C₂₃H₂₀N₂O₅S
Molecular Weight:436.488
Hs Code.:

Synonyms:1-(2,4-dihydroxy-benzenesulfonyl)-3-phenyl-5-[1-pyridin-2-ymethylidene]-piperidin-4-one

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Chemical Property of 1-(2,4-dihydroxy-benzenesulfonyl)-3-phenyl-5-[1-pyridin-2-ymethylidene]-piperidin-4-one

Chemical Property:

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Technology Process of 1-(2,4-dihydroxy-benzenesulfonyl)-3-phenyl-5-[1-pyridin-2-ymethylidene]-piperidin-4-one

There total 8 articles about 1-(2,4-dihydroxy-benzenesulfonyl)-3-phenyl-5-[1-pyridin-2-ymethylidene]-piperidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1096168-17-0
3-phenyl-5-[1-pyridin-2-yl-methylidene]-piperidin-4-one

: 134479-01-9
2,4-dihydroxybenzene sulphonylchloride

: 1096167-32-6
1-(2,4-dihydroxy-benzenesulfonyl)-3-phenyl-5-[1-pyridin-2-ymethylidene]-piperidin-4-one

Guidance literature:: 3-phenyl-5-[1-pyridin-2-yl-methylidene]-piperidin-4-one; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.25h;

2,4-dihydroxybenzene sulphonylchloride; In tetrahydrofuran; for 5h; Heating / reflux;

Reference yield:

: 632352-54-6
3-[benzyl-(2-ethoxycarbonyl-ethyl)-amino]-2-phenyl-propionic acid ethy ester

: 1096167-32-6
1-(2,4-dihydroxy-benzenesulfonyl)-3-phenyl-5-[1-pyridin-2-ymethylidene]-piperidin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 10 h / 20 °C / 10343.2 Torr

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / 0 - 10 °C

3.1: hydrogenchloride; water / 4 h / Heating / reflux

4.1: sodium hydroxide / methanol; water / 4 h / 20 °C

5.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

5.2: 5 h / Heating / reflux

With hydrogenchloride; sodium hydroxide; water; hydrogen; sodium hydride; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water;

Reference yield:

: 101-97-3
Ethyl 2-phenylethanoate

: 1096167-32-6
1-(2,4-dihydroxy-benzenesulfonyl)-3-phenyl-5-[1-pyridin-2-ymethylidene]-piperidin-4-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 6 - 7 h / 90 °C

2.1: toluene / 4 - 6 h / Heating / reflux

3.1: acetic acid / 12 h / Heating / reflux

4.1: hydrogen / palladium 10% on activated carbon / methanol / 10 h / 20 °C / 10343.2 Torr

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / 0 - 10 °C

6.1: hydrogenchloride; water / 4 h / Heating / reflux

7.1: sodium hydroxide / methanol; water / 4 h / 20 °C

8.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

8.2: 5 h / Heating / reflux

With hydrogenchloride; sodium hydroxide; water; hydrogen; sodium hydride; potassium carbonate; acetic acid; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; water; toluene;