2-(5-(4-chloro-3-methoxyphenyl)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-3-yl)-N-methylacetamide

Base Information

Chemical Name:2-(5-(4-chloro-3-methoxyphenyl)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-3-yl)-N-methylacetamide
CAS No.:1607023-31-3
Molecular Formula:C₁₆H₁₅ClN₄O₃
Molecular Weight:346.773
Hs Code.:

Synonyms:2-(5-(4-chloro-3-methoxyphenyl)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-3-yl)-N-methylacetamide

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Chemical Property of 2-(5-(4-chloro-3-methoxyphenyl)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-3-yl)-N-methylacetamide

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Technology Process of 2-(5-(4-chloro-3-methoxyphenyl)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-3-yl)-N-methylacetamide

There total 5 articles about 2-(5-(4-chloro-3-methoxyphenyl)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-3-yl)-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1607024-73-6
2-[5-(4-chloro-3-methoxyphenyl)-7-oxo-4H,7H-pyrazolo[1,5-a]pyrimidin-3-yl]acetic acid

: 593-51-1
methylamine hydrochloride

: 1607023-31-3
2-(5-(4-chloro-3-methoxyphenyl)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-3-yl)-N-methylacetamide

Guidance literature:: With benzotriazol-1-ol; 1,2-dichloro-ethane; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 89283-73-8
(E,Z)-2-formylsuccinonitrile potassium salt

: 1607023-31-3
2-(5-(4-chloro-3-methoxyphenyl)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-3-yl)-N-methylacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid / ethanol / 2 h / 80 °C

2: acetic acid; hydrazine hydrate / ethanol / 1 h / 80 °C

3: toluene-4-sulfonic acid / butan-1-ol / 1 h / 130 °C

4: water; potassium hydroxide / ethanol / 1 h / 70 °C

5: benzotriazol-1-ol; 1,2-dichloro-ethane; triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

With water; benzotriazol-1-ol; toluene-4-sulfonic acid; hydrazine hydrate; acetic acid; 1,2-dichloro-ethane; triethylamine; potassium hydroxide; In ethanol; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 1607019-62-4
2-(5-amino-1H-pyrazol-4-yl)acetonitrile

: 1607023-31-3
2-(5-(4-chloro-3-methoxyphenyl)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-3-yl)-N-methylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / butan-1-ol / 1 h / 130 °C

2: water; potassium hydroxide / ethanol / 1 h / 70 °C

3: benzotriazol-1-ol; 1,2-dichloro-ethane; triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

With water; benzotriazol-1-ol; toluene-4-sulfonic acid; 1,2-dichloro-ethane; triethylamine; potassium hydroxide; In ethanol; N,N-dimethyl-formamide; butan-1-ol;