methyl 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

Base Information

• Chemical Name: methyl 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate
• CAS No.: 1426575-26-9
• Molecular Formula: C₁₅H₁₁ClN₂O₂
• Molecular Weight: 286.718
• Mol file: 1426575-26-9.mol

Synonyms:methyl 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

Chemical Property of methyl 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

There total 1 articles about methyl 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C15H11ClN4O2 → methyl 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate (1426575-26-9)

Guidance literature:

In toluene; at 200 ℃; for 0.2h; Microwave irradiation;

DOI:10.1016/j.bmcl.2013.01.066

Reference yield: 97.0%

methyl 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate (1426575-26-9) → C14H9ClN2O2 (1431663-20-5)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2013.01.066

Reference yield:

methyl 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate (1426575-26-9) → 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine (918516-27-5)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium hydroxide / tetrahydrofuran

2: quinoline; copper chromite / 0.2 h / 220 °C / Microwave irradiation

With quinoline; copper chromite; lithium hydroxide; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2013.01.066

Downstream raw materials:

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

C₂₀H₁₃ClN₂O

C₁₄H₉ClN₂O₂