1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)-

Base Information

• Chemical Name: 1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)-
• CAS No.: 918516-27-5
• Molecular Formula: C13H9ClN2
• Molecular Weight: 228.681
• Hs Code.: 2933990090
• Mol file: 918516-27-5.mol

Synonyms:5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine; 5-(4-chlorophenyl)-1h-pyrrolo(2,3-b)pyridine

Chemical Property of 1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)-

Chemical Property:

• PKA: 13.51±0.40(Predicted)
• PSA: 28.68000
• Density: 1.3±0.1 g/cm³
• LogP: 3.88330
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

5-(4-Chlorophenyl)-1h-pyrrolo[2,3-B]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)-

There total 25 articles about 1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-Chlorophenylboronic acid (1679-18-1) + 5-bromo-1H-pyrrolo[2,3-b]pyridine (183208-35-7) → 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine (918516-27-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In Dimethyl ether; water; Solvent; Temperature; Reflux;

Reference yield: 81.3%

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid → 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine (918516-27-5)

Guidance literature:

With sodium hydroxide; In water; N,N-dimethyl-formamide; at 100 ℃; for 10h;

Reference yield: 80.0%

5-(4-Cl-phenyl)azaindole (1356397-48-2) → 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine (918516-27-5)

Guidance literature:

With potassium tert-butylate; In 1-methyl-pyrrolidin-2-one; at 20 - 120 ℃; for 2h; Product distribution / selectivity;

upstream raw materials:

5-bromo-2-pyridylamine

4-Chlorophenylboronic acid

5-(4-chlorophenyl)pyridin-2-ylamine

C₁₁H₈BrClN₂

Downstream raw materials:

vemurafenib

C₂₀H₁₃ClN₂O