7-methoxy-3-(4-methoxyphenyl)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)isoquinolin-1(2H)-one

Base Information

• Chemical Name: 7-methoxy-3-(4-methoxyphenyl)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)isoquinolin-1(2H)-one
• CAS No.: 1419829-22-3
• Molecular Formula: C₃₀H₃₂N₂O₄
• Molecular Weight: 484.595
• Mol file: 1419829-22-3.mol

Synonyms:7-methoxy-3-(4-methoxyphenyl)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)isoquinolin-1(2H)-one

Chemical Property of 7-methoxy-3-(4-methoxyphenyl)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)isoquinolin-1(2H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-methoxy-3-(4-methoxyphenyl)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)isoquinolin-1(2H)-one

There total 7 articles about 7-methoxy-3-(4-methoxyphenyl)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)isoquinolin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

2-(4-hydroxyphenyl)-7-methoxy-3-(4-methoxyphenyl)isoquinolin-1(2H)-one (1419827-39-6) + 1-(3-chloropropyl)pyrrolidine hydrochloride (57616-69-0) → 7-methoxy-3-(4-methoxyphenyl)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)isoquinolin-1(2H)-one (1419829-22-3)

Guidance literature:

With potassium carbonate; potassium iodide; In acetone; for 12h; Reflux;

DOI:10.1016/j.bmcl.2014.03.042

Reference yield:

6-methoxy-3-(trichloromethyl)isobenzofuran-1(3H)-one (82735-28-2) → 7-methoxy-3-(4-methoxyphenyl)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)isoquinolin-1(2H)-one (1419829-22-3)

Guidance literature:

Multi-step reaction with 5 steps

1: zinc; acetic acid / 0.58 h / 20 °C / Reflux

2: sulfuric acid / 0.5 h / 20 °C

3: 6 h / 200 °C

4: acetic acid / 4 h / Reflux

5: potassium carbonate; potassium iodide / acetone / 12 h / Reflux

With sulfuric acid; potassium carbonate; acetic acid; potassium iodide; zinc; In acetone;

DOI:10.1016/j.bmcl.2014.03.042

Reference yield:

2-(β,β-dichloroethenyl)-5-methoxybenzoic acid (586415-11-4) → 7-methoxy-3-(4-methoxyphenyl)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)isoquinolin-1(2H)-one (1419829-22-3)

Guidance literature:

Multi-step reaction with 4 steps

1: sulfuric acid / 0.5 h / 20 °C

2: 6 h / 200 °C

3: acetic acid / 4 h / Reflux

4: potassium carbonate; potassium iodide / acetone / 12 h / Reflux

With sulfuric acid; potassium carbonate; acetic acid; potassium iodide; In acetone;

DOI:10.1016/j.bmcl.2014.03.042

upstream raw materials:

6-methoxy-3-(trichloromethyl)isobenzofuran-1(3H)-one

2-(4-hydroxyphenyl)-7-methoxy-3-(4-methoxyphenyl)isoquinolin-1(2H)-one

1-(3-chloropropyl)pyrrolidine hydrochloride

2-(β,β-dichloroethenyl)-5-methoxybenzoic acid