3-(2,6-dichloro-benzyl)-2-methyl-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

Base Information

Chemical Name:3-(2,6-dichloro-benzyl)-2-methyl-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester
CAS No.:909867-56-7
Molecular Formula:C₂₁H₁₉Cl₂NO₃
Molecular Weight:404.293
Hs Code.:

3-(2,6-dichloro-benzyl)-2-methyl-4-oxo-3,4-dihydro-2<i>H</i>-pyridine-1-carboxylic acid benzyl ester

Synonyms:3-(2,6-dichloro-benzyl)-2-methyl-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

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Chemical Property of 3-(2,6-dichloro-benzyl)-2-methyl-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

Chemical Property:

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Technology Process of 3-(2,6-dichloro-benzyl)-2-methyl-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

There total 1 articles about 3-(2,6-dichloro-benzyl)-2-methyl-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 20443-98-5
2,6-Dichlorobenzyl bromide

: 190906-91-3
3,4-dihydro-2-methyl-4-oxo-1(2H)-pyridinecarboxylic acid phenylmethyl ester

: 909867-56-7
3-(2,6-dichloro-benzyl)-2-methyl-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

Guidance literature:: 3,4-dihydro-2-methyl-4-oxo-1(2H)-pyridinecarboxylic acid phenylmethyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 0 ℃;

2,6-Dichlorobenzyl bromide; In tetrahydrofuran; at -78 ℃; for 1h;
DOI:10.1246/cl.2006.712

Reference yield: 71.0%

: 909867-56-7
3-(2,6-dichloro-benzyl)-2-methyl-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

: 69739-34-0
t-butyldimethylsiyl triflate

: 909867-57-8
4-(tert-butyl-dimethyl-silanyloxy)-3-(2,6-dichloro-benzyl)-2-methyl-pyridine

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1246/cl.2006.712

Reference yield:

: 909867-56-7
3-(2,6-dichloro-benzyl)-2-methyl-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

: 478246-05-8
3-(2,6-dichlorobenzyl)-2-methylpyridin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

2: 34 percent / DDQ; NaHCO₃ / dioxane / 20 °C

With sodium hydrogencarbonate; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; dichloromethane;
DOI:10.1246/cl.2006.712