2,5-cis-1-benzyl-2-(2-p-bromobenzoyloxyethyl)-7-oxa-1-azaspiro<4.4.>nonan-6-one

Base Information

Chemical Name:2,5-cis-1-benzyl-2-(2-p-bromobenzoyloxyethyl)-7-oxa-1-azaspiro<4.4.>nonan-6-one
CAS No.:127655-08-7
Molecular Formula:C₂₃H₂₄BrNO₄
Molecular Weight:458.352
Hs Code.:

Synonyms:2,5-cis-1-benzyl-2-(2-p-bromobenzoyloxyethyl)-7-oxa-1-azaspiro<4.4.>nonan-6-one

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Chemical Property of 2,5-cis-1-benzyl-2-(2-p-bromobenzoyloxyethyl)-7-oxa-1-azaspiro<4.4.>nonan-6-one

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Technology Process of 2,5-cis-1-benzyl-2-(2-p-bromobenzoyloxyethyl)-7-oxa-1-azaspiro<4.4.>nonan-6-one

There total 8 articles about 2,5-cis-1-benzyl-2-(2-p-bromobenzoyloxyethyl)-7-oxa-1-azaspiro<4.4.>nonan-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 127655-05-4
2,5-cis-1-benzyl-2-(2-hydroxyethyl)-7-oxa-1-azaspiro<4.4>nonan-6-one

: 586-75-4
4-chlorobenzoyl chloride

: 127655-08-7
2,5-cis-1-benzyl-2-(2-p-bromobenzoyloxyethyl)-7-oxa-1-azaspiro<4.4.>nonan-6-one

Guidance literature:: dmap; In pyridine; for 42h; Ambient temperature;

Reference yield:

: 100118-09-0
diethyl hexa-1,5-diyne-1,6-dicarboxylate

: 127655-08-7
2,5-cis-1-benzyl-2-(2-p-bromobenzoyloxyethyl)-7-oxa-1-azaspiro<4.4.>nonan-6-one

Guidance literature:: Multi-step reaction with 7 steps

1: 1.77 g / ethanol / 1.) r.t., 2 h, 2.) reflux, 2 h

2: 99 percent / H₂ / 10percent Pd-C / acetic acid / 17 h / 3898.2 Torr

3: 85 percent / K₂CO₃ / acetone / 2 h / Ambient temperature

4: LiAlH₄ / diethyl ether / 0.08 h / 0 °C

5: 64 percent / 4-DMAP / CH₂Cl₂ / 0.5 h / 0 °C

6: 65 percent / AIBN / benzene / 3.5 h / Heating

7: 76 percent / 4-DMAP / pyridine / 42 h / Ambient temperature

With dmap; lithium aluminium tetrahydride; hydrogen; potassium carbonate; dmap; palladium on activated charcoal; 2,2'-azobis(isobutyronitrile); In pyridine; diethyl ether; ethanol; dichloromethane; acetic acid; acetone; benzene;

Reference yield:

: 100-39-0
benzyl bromide

: 127655-08-7
2,5-cis-1-benzyl-2-(2-p-bromobenzoyloxyethyl)-7-oxa-1-azaspiro<4.4.>nonan-6-one

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / K₂CO₃ / acetone / 2 h / Ambient temperature

2: LiAlH₄ / diethyl ether / 0.08 h / 0 °C

3: 64 percent / 4-DMAP / CH₂Cl₂ / 0.5 h / 0 °C

4: 65 percent / AIBN / benzene / 3.5 h / Heating

5: 76 percent / 4-DMAP / pyridine / 42 h / Ambient temperature

With dmap; lithium aluminium tetrahydride; potassium carbonate; dmap; 2,2'-azobis(isobutyronitrile); In pyridine; diethyl ether; dichloromethane; acetone; benzene;