(E)-3-{3-[(tert-butyldimethylsilyl)oxy]phenyl}acrylic acid

Base Information

• Chemical Name: (E)-3-{3-[(tert-butyldimethylsilyl)oxy]phenyl}acrylic acid
• CAS No.: 1449014-71-4
• Molecular Formula: C₁₅H₂₂O₃Si
• Molecular Weight: 278.423
• Mol file: 1449014-71-4.mol

Synonyms:(E)-3-{3-[(tert-butyldimethylsilyl)oxy]phenyl}acrylic acid

Chemical Property of (E)-3-{3-[(tert-butyldimethylsilyl)oxy]phenyl}acrylic acid

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (E)-3-{3-[(tert-butyldimethylsilyl)oxy]phenyl}acrylic acid

There total 1 articles about (E)-3-{3-[(tert-butyldimethylsilyl)oxy]phenyl}acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

3-hydroxy-trans-cinnamic acid (14755-02-3,588-30-7) + tert-butyldimethylsilyl chloride (18162-48-6) → (E)-3-{3-[(tert-butyldimethylsilyl)oxy]phenyl}acrylic acid (1449014-71-4)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1002/cmdc.201500422

Reference yield: 83.0%

(E)-3-{3-[(tert-butyldimethylsilyl)oxy]phenyl}acrylic acid (1449014-71-4) + salicylaldehyde (90-02-8) → 2-formylphenyl (E)-3-(3-((tert-butyldimethylsilyl)oxy)phenyl)acrylate

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃;

DOI:10.1002/anie.201705746

Reference yield: 70.0%

(E)-3-{3-[(tert-butyldimethylsilyl)oxy]phenyl}acrylic acid (1449014-71-4) + (Z)-2-[(tert-butyldimethylsilyl)oxy]-3-methoxy-6-(3,4,5-trimethoxystyryl)aniline → (E)-N-(2-hydroxy-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3-(3-hydroxyphenyl)acrylamide

Guidance literature:

(E)-3-{3-[(tert-butyldimethylsilyl)oxy]phenyl}acrylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; for 3h;

(Z)-2-[(tert-butyldimethylsilyl)oxy]-3-methoxy-6-(3,4,5-trimethoxystyryl)aniline; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 12h;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

upstream raw materials:

3-hydroxy-trans-cinnamic acid

tert-butyldimethylsilyl chloride

Downstream raw materials:

C₃₀H₃₂O₆

C₃₂H₃₆O₆

C₃₄H₄₀O₆

C₃₆H₄₄O₆