Technology Process of N-formyl-2-phenylpyrrolidine
There total 5 articles about N-formyl-2-phenylpyrrolidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate;
In
tetrahydrofuran; water;
at 0 - 20 ℃;
for 6h;
Inert atmosphere;
DOI:10.1021/acs.orglett.1c00200
- Guidance literature:
-
With
aluminium trichloride;
for 0.5h;
Heating;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: thionyl chloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere
1.2: 1 h / Inert atmosphere
2.1: boron trifluoride diethyl etherate / 1,2-dichloro-ethane / 2.5 h / 90 °C / Inert atmosphere
3.1: sodium tetrahydroborate / tetrahydrofuran; water / 6 h / 0 - 20 °C / Inert atmosphere
With
sodium tetrahydroborate; thionyl chloride; boron trifluoride diethyl etherate;
In
tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane;
2.1: |Schmidt Reaction;
DOI:10.1021/acs.orglett.1c00200
