3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropyl]methoxy)phenyl]propanoic acid trifluoroacetate

Base Information

Chemical Name:3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropyl]methoxy)phenyl]propanoic acid trifluoroacetate
CAS No.:1445981-44-1
Molecular Formula:C₂HF₃O₂*C₂₅H₂₆Cl₂N₂O₄
Molecular Weight:603.422
Hs Code.:

3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropyl]methoxy)phenyl]propanoic acid trifluoroacetate

Synonyms:3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropyl]methoxy)phenyl]propanoic acid trifluoroacetate

Suppliers and Price of 3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropyl]methoxy)phenyl]propanoic acid trifluoroacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropyl]methoxy)phenyl]propanoic acid trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropyl]methoxy)phenyl]propanoic acid trifluoroacetate

There total 13 articles about 3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropyl]methoxy)phenyl]propanoic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 1445984-97-3
tert-butyl 3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropyl]methoxy)phenyl]propanoate

: 76-05-1
trifluoroacetic acid

: 1445981-44-1
3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropyl]methoxy)phenyl]propanoic acid trifluoroacetate

Guidance literature:: tert-butyl 3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropyl]methoxy)phenyl]propanoate; With trimethylsilyl bromide; In dichloromethane; at 0 - 20 ℃; for 1.5h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 1224640-11-2
1-cyclopropyl-4-hydroxy-1,2,3,4-tetrahydroquinoxaline-2,3-dione

: 1445981-44-1
3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropyl]methoxy)phenyl]propanoic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine / N,N-dimethyl-formamide / 2 h / 135 °C / Inert atmosphere

2: borane-THF / tetrahydrofuran / 4 h / 50 °C

3: triethylamine / dichloromethane / 20 °C

4: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 70 °C

5: trimethylsilyl bromide / dichloromethane / 1.5 h / 0 - 20 °C

With borane-THF; trimethylsilyl bromide; potassium carbonate; triethylamine; triphenylphosphine; potassium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1224640-12-3
1-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-2,3-dione

: 1445981-44-1
3-[2,5-dichloro-4-([1-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]cyclopropyl]methoxy)phenyl]propanoic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: borane-THF / tetrahydrofuran / 4 h / 50 °C

2: triethylamine / dichloromethane / 20 °C

3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 70 °C

4: trimethylsilyl bromide / dichloromethane / 1.5 h / 0 - 20 °C

With borane-THF; trimethylsilyl bromide; potassium carbonate; triethylamine; potassium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;