A-TOSYL-(4-CHLOROBENZYL) ISOCYANIDE

Base Information

• Chemical Name: A-TOSYL-(4-CHLOROBENZYL) ISOCYANIDE
• CAS No.: 918892-30-5
• Molecular Formula: C₁₅H₁₂ClNO₂S
• Molecular Weight: 305.785
• Hs Code.: 2926909090
• Mol file: 918892-30-5.mol

Synonyms:(4-Chlorophenyl)(isocyano)methyl 4-methylphenyl sulphone;a-Tosyl-(4-chlorobenzyl) isocyanide;OR1748;

Chemical Property of A-TOSYL-(4-CHLOROBENZYL) ISOCYANIDE

Chemical Property:

• PSA: 42.52000
• LogP: 4.35170
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

a-Tosyl-(4-chlorobenzyl) isocyanide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of A-TOSYL-(4-CHLOROBENZYL) ISOCYANIDE

There total 8 articles about A-TOSYL-(4-CHLOROBENZYL) ISOCYANIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-{(4-chlorophenyl)[(4-methylphenyl)sulfonyl]methyl}formamide → (4-chlorophenyl)(isocyano)methyl 4-methylphenylsulfone (918892-30-5)

Guidance literature:

With triethylamine; trichlorophosphate; In 1,2-dimethoxyethane; for 0.75h; Cooling;

DOI:10.1021/acs.jmedchem.8b01464

Reference yield:

p-toluene sulfinic acid (536-57-2) → (4-chlorophenyl)(isocyano)methyl 4-methylphenylsulfone (918892-30-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: chloro-trimethyl-silane / acetonitrile; toluene / 3 h / 50 °C / Inert atmosphere

1.2: 16 h / 50 °C

2.1: triethylamine; trichlorophosphate / tetrahydrofuran / 1.5 h / 0 °C

With chloro-trimethyl-silane; triethylamine; trichlorophosphate; In tetrahydrofuran; toluene; acetonitrile;

Reference yield:

sodium 4-methylbenzenesulfinate (824-79-3) → (4-chlorophenyl)(isocyano)methyl 4-methylphenylsulfone (918892-30-5)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / water; tert-butyl methyl ether / 20 °C

2: acetonitrile; toluene / 16 h / 55 °C

3: trichlorophosphate; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

With hydrogenchloride; triethylamine; trichlorophosphate; In tetrahydrofuran; tert-butyl methyl ether; water; toluene; acetonitrile;

DOI:10.1039/c9ob00660e

upstream raw materials:

4-chlorobenzaldehyde

toluene-4-sulfonic acid

p-toluene sulfinic acid

sodium tosylate

Downstream raw materials:

4,5-bis(4-chlorophenyl)-1,3-oxazole