Fmoc-(p-terphenyl)alanine

Base Information

Chemical Name:Fmoc-(p-terphenyl)alanine
CAS No.:1381789-61-2
Molecular Formula:C₃₆H₂₉NO₄
Molecular Weight:539.631
Hs Code.:

Synonyms:Fmoc-(p-terphenyl)alanine

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Chemical Property of Fmoc-(p-terphenyl)alanine

Chemical Property:

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Technology Process of Fmoc-(p-terphenyl)alanine

There total 5 articles about Fmoc-(p-terphenyl)alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4326-36-7
(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester

: 1381789-61-2
Fmoc-(p-terphenyl)alanine

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / dichloromethane / 0.5 h / -15 °C / Inert atmosphere

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; N,N-dimethyl-formamide / 80 °C / Inert atmosphere

3.1: sodium hydroxide / methanol; tetrahydrofuran / 20 °C

3.2: pH 3

4.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

5.1: sodium hydrogencarbonate / tetrahydrofuran; water / 20 °C / pH 10

5.2: pH 3

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; potassium carbonate; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 2.1: |Suzuki Coupling;
DOI:10.1016/j.bmc.2012.07.010

Reference yield:

: 60-18-4,18875-48-4,25619-78-7,30704-25-7
L-tyrosine

: 1381789-61-2
Fmoc-(p-terphenyl)alanine

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride / 4 h / Reflux

2.1: triethylamine / methanol / 20 °C / Cooling with ice; Inert atmosphere

3.1: pyridine / dichloromethane / 0.5 h / -15 °C / Inert atmosphere

4.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; N,N-dimethyl-formamide / 80 °C / Inert atmosphere

5.1: sodium hydroxide / methanol; tetrahydrofuran / 20 °C

5.2: pH 3

6.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

7.1: sodium hydrogencarbonate / tetrahydrofuran; water / 20 °C / pH 10

7.2: pH 3

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; sodium hydrogencarbonate; potassium carbonate; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 4.1: |Suzuki Coupling;
DOI:10.1016/j.bmc.2012.07.010

Reference yield:

: 1080-06-4
L-Tyr-OMe

: 1381789-61-2
Fmoc-(p-terphenyl)alanine

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / methanol / 20 °C / Cooling with ice; Inert atmosphere

2.1: pyridine / dichloromethane / 0.5 h / -15 °C / Inert atmosphere

3.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; N,N-dimethyl-formamide / 80 °C / Inert atmosphere

4.1: sodium hydroxide / methanol; tetrahydrofuran / 20 °C

4.2: pH 3

5.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

6.1: sodium hydrogencarbonate / tetrahydrofuran; water / 20 °C / pH 10

6.2: pH 3

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; potassium carbonate; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 3.1: |Suzuki Coupling;
DOI:10.1016/j.bmc.2012.07.010