5-Fluoro-2-methoxyphenylboronic acid pinacol ester

Base Information

• Chemical Name: 5-Fluoro-2-methoxyphenylboronic acid pinacol ester
• CAS No.: 1383806-53-8
• Molecular Formula: C₁₃H₁₈BFO₃
• Molecular Weight: 252.094
• Hs Code.: 2931900090
• Mol file: 1383806-53-8.mol

Synonyms:C₁₃H₁₈BFO₃

Chemical Property of 5-Fluoro-2-methoxyphenylboronic acid pinacol ester

Chemical Property:

• Boiling Point: 340.4±32.0 °C(Predicted)
• Density: 1.08±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

5-Fluoro-2-methoxyphenylboronicAcidPinacolEster ^*data from reagent suppliers

Safty Information:

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Technology Process of 5-Fluoro-2-methoxyphenylboronic acid pinacol ester

There total 3 articles about 5-Fluoro-2-methoxyphenylboronic acid pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-fluoro-4-methoxybenzene (459-60-9) + 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) → C13H18BFO3 (1383806-53-8)

Guidance literature:

With C₂₆H₄₅OSiY; In hexane; at 100 ℃; for 24h; regioselective reaction;

DOI:10.1021/acscatal.8b01364

Reference yield:

2-bromo-4-fluoro-1-methoxybenzene (452-08-4) + bis(pinacol)diborane (73183-34-3) → C13H18BFO3 (1383806-53-8)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In N,N-dimethyl-formamide; at 16 - 110 ℃; for 16h;

Reference yield:

1-fluoro-4-methoxybenzene (459-60-9) + bis(pinacol)diborane (73183-34-3) → C13H18BFO3 (1383806-53-8) + 2-(2-fluoro-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Guidance literature:

With n-butyllithium; C₂₈H₄₁ClNPPtSi; In hexane; 1,3,5-trimethyl-benzene; at 20 - 150 ℃; for 4h; Overall yield = 92 %; Overall yield = 92.8 mg; regioselective reaction; Inert atmosphere;

DOI:10.1039/c5cc07263h

upstream raw materials:

1-fluoro-4-methoxybenzene

bis(pinacol)diborane

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

2-bromo-4-fluoro-1-methoxybenzene

Downstream raw materials:

C₂₃H₂₄FN₃O₃

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