(E)-2,2,4-trimethyl-5-phenylpent-4-enylamine

Base Information

• Chemical Name: (E)-2,2,4-trimethyl-5-phenylpent-4-enylamine
• CAS No.: 1426431-58-4
• Molecular Formula: C₁₄H₂₁N
• Molecular Weight: 203.327
• Mol file: 1426431-58-4.mol

Synonyms:(E)-2,2,4-trimethyl-5-phenylpent-4-enylamine

Chemical Property of (E)-2,2,4-trimethyl-5-phenylpent-4-enylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2,2,4-trimethyl-5-phenylpent-4-enylamine

There total 5 articles about (E)-2,2,4-trimethyl-5-phenylpent-4-enylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(E)-2,2,4-Trimethyl-5-phenyl-4-pentenenitrile → (E)-2,2,4-trimethyl-5-phenylpent-4-enylamine (1426431-58-4)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; for 10h; Inert atmosphere;

DOI:10.1055/s-0032-1317843

Reference yield:

benzaldehyde (100-52-7) → (E)-2,2,4-trimethyl-5-phenylpent-4-enylamine (1426431-58-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 0.5 h / Inert atmosphere

2.1: lithium aluminium tetrahydride / diethyl ether / 10 h / 0 °C / Inert atmosphere

3.1: thionyl chloride / diethyl ether / 0.5 h / 0 °C / Inert atmosphere

4.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

4.2: 2 h / -78 - 20 °C / Inert atmosphere

5.1: lithium aluminium tetrahydride / diethyl ether / 10 h / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; thionyl chloride; sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; mineral oil; 1.1: |Horner-Wadsworth-Emmons Olefination / 1.2: |Horner-Wadsworth-Emmons Olefination;

DOI:10.1055/s-0032-1317843

Reference yield:

ethyl (E)-2-methyl-3-phenyl-2-propenoate (7042-33-3) → (E)-2,2,4-trimethyl-5-phenylpent-4-enylamine (1426431-58-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / diethyl ether / 10 h / 0 °C / Inert atmosphere

2.1: thionyl chloride / diethyl ether / 0.5 h / 0 °C / Inert atmosphere

3.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

3.2: 2 h / -78 - 20 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride / diethyl ether / 10 h / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; thionyl chloride; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether;

DOI:10.1055/s-0032-1317843

upstream raw materials:

benzaldehyde

ethyl (E)-2-methyl-3-phenyl-2-propenoate

(E)-3-phenyl-2-methyl-2-propenol

<(E)-3-chloro-2-methyl-1-propenyl>benzene

Downstream raw materials:

C₁₄H₂₁N

2-benzyl-2,4,4-trimethyl-1-(4-methylbenzenesulfonyl)pyrrolidine

Refernces