3-(methylthiomethoxy)-7-(benzyloxycarbonyloxy)ursodeoxycholic acid benzyl ester

Base Information

• Chemical Name: 3-(methylthiomethoxy)-7-(benzyloxycarbonyloxy)ursodeoxycholic acid benzyl ester
• CAS No.: 1486547-62-9
• Molecular Formula: C₄₁H₅₆O₆S
• Molecular Weight: 676.958
• Mol file: 1486547-62-9.mol

Synonyms:3-(methylthiomethoxy)-7-(benzyloxycarbonyloxy)ursodeoxycholic acid benzyl ester

Chemical Property of 3-(methylthiomethoxy)-7-(benzyloxycarbonyloxy)ursodeoxycholic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-(methylthiomethoxy)-7-(benzyloxycarbonyloxy)ursodeoxycholic acid benzyl ester

There total 4 articles about 3-(methylthiomethoxy)-7-(benzyloxycarbonyloxy)ursodeoxycholic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

7-(benzyloxycarbonyloxy)ursodeoxycholic acid benzyl ester (1486547-54-9) + dimethyl sulfoxide (67-68-5,8070-53-9) → 3-(methylthiomethoxy)-7-(benzyloxycarbonyloxy)ursodeoxycholic acid benzyl ester (1486547-62-9)

Guidance literature:

With acetic anhydride; acetic acid; In dimethyl sulfoxide; at 20 ℃; for 24h;

DOI:10.1002/cmdc.201300059

Reference yield:

benzyl bromide (100-39-0) → 3-(methylthiomethoxy)-7-(benzyloxycarbonyloxy)ursodeoxycholic acid benzyl ester (1486547-62-9)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 3 h / 80 °C

2: pyridine / dichloromethane / 1.5 h

3: acetic anhydride; acetic acid / dimethyl sulfoxide / 24 h / 20 °C

With pyridine; acetic anhydride; potassium carbonate; acetic acid; In dichloromethane; dimethyl sulfoxide; acetonitrile;

DOI:10.1002/cmdc.201300059

Reference yield:

ursodeoxycholic acid (128-13-2) → 3-(methylthiomethoxy)-7-(benzyloxycarbonyloxy)ursodeoxycholic acid benzyl ester (1486547-62-9)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 3 h / 80 °C

2: pyridine / dichloromethane / 1.5 h

3: acetic anhydride; acetic acid / dimethyl sulfoxide / 24 h / 20 °C

With pyridine; acetic anhydride; potassium carbonate; acetic acid; In dichloromethane; dimethyl sulfoxide; acetonitrile;

DOI:10.1002/cmdc.201300059

upstream raw materials:

benzyl bromide

ursodeoxycholic acid

benzyl (4R)-4-((3R,7S,10S,13R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate

7-(benzyloxycarbonyloxy)ursodeoxycholic acid benzyl ester

Downstream raw materials:

3-(chloromethoxy)-7-(benzyloxycarbonyloxy)ursodeoxycholic acid benzyl ester