(E)-2-(4-oxohexylidene)cyclohexanol

Base Information

Chemical Name:(E)-2-(4-oxohexylidene)cyclohexanol
CAS No.:76042-66-5
Molecular Formula:C₁₂H₂₀O₂
Molecular Weight:196.29
Hs Code.:

Synonyms:(E)-2-(4-oxohexylidene)cyclohexanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-2-(4-oxohexylidene)cyclohexanol

Chemical Property:

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Technology Process of (E)-2-(4-oxohexylidene)cyclohexanol

There total 11 articles about (E)-2-(4-oxohexylidene)cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 76042-66-5
(E)-2-(4-oxohexylidene)cyclohexanol

Guidance literature:: Multi-step reaction with 7 steps

1: 86 percent / lithium diisopropylamide / tetrahydrofuran / -78 °C

2: 1.) phosphorus oxychloride, HMPA, 2.) pyridine / 1.) room temperature -> 50 deg C, 2.) 50 deg C -> 100 deg C

3: 83 percent / DIBAL-H / hexane; tetrahydrofuran / -78 °C

4: 60 percent / 48percent fluoboric acid / diethyl ether / 1.17 h

5: diethyl ether / 5.5 h / -78 °C

6: MCPBA, 0.5 M sodium bicarbonate / CH₂Cl₂ / 5 h / 0 °C

7: NaOCH₃ / methanol / Ambient temperature

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; tetrafluoroboric acid; sodium methylate; diisobutylaluminium hydride; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; trichlorophosphate; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane;
DOI:10.1021/ja00547a015

Reference yield:

: 76043-12-4
2-(cyclohexen-1-yl)cyclobutanone

: 76042-66-5
(E)-2-(4-oxohexylidene)cyclohexanol

Guidance literature:: Multi-step reaction with 3 steps

1: diethyl ether / 5.5 h / -78 °C

2: MCPBA, 0.5 M sodium bicarbonate / CH₂Cl₂ / 5 h / 0 °C

3: NaOCH₃ / methanol / Ambient temperature

With sodium methylate; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/ja00547a015

Reference yield:

: 76042-22-3
(E)-2-<(1-((2,6-dimethoxyphenyl)thio)cyclopropyl)methylene>cyclohexanone

: 76042-66-5
(E)-2-(4-oxohexylidene)cyclohexanol

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / DIBAL-H / toluene / 1.) -78 deg C, 30 min, 2.) 0 deg C, 2 h

2: 70 percent / 48percent fluoboric acid / diethyl ether

3: diethyl ether / 5.5 h / -78 °C

4: MCPBA, 0.5 M sodium bicarbonate / CH₂Cl₂ / 5 h / 0 °C

5: NaOCH₃ / methanol / Ambient temperature

With tetrafluoroboric acid; sodium methylate; diisobutylaluminium hydride; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In methanol; diethyl ether; dichloromethane; toluene;
DOI:10.1021/ja00547a015