N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-4-(dimethylamino)benzamide

Base Information

• Chemical Name: N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-4-(dimethylamino)benzamide
• CAS No.: 1354054-23-1
• Molecular Formula: C₂₀H₂₄N₄O₂S₂
• Molecular Weight: 416.568

Synonyms:N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-4-(dimethylamino)benzamide

Chemical Property of N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-4-(dimethylamino)benzamide

Chemical Property:

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Technology Process of N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-4-(dimethylamino)benzamide

There total 1 articles about N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-4-(dimethylamino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

p-N,N-dimethylaminobenzoic acid (619-84-1) + 2-amino-5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-thiazole (224436-97-9) → N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-4-(dimethylamino)benzamide (1354054-23-1)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/jlcr.1922

Reference yield: 90.0%

N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-4-(dimethylamino)benzamide (1354054-23-1) + methyl trifluoromethanesulfonate (333-27-7) → N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-4-(trimethylammonium)benzamide triflate (1354054-21-9)

Guidance literature:

In nitromethane; at 20 ℃; for 4h;

DOI:10.1002/jlcr.1922

upstream raw materials:

p-N,N-dimethylaminobenzoic acid

2-amino-5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-thiazole

Downstream raw materials:

N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-4-(trimethylammonium)benzamide triflate

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