ethyl (2RS)-2-(3,4-dichlorophenyl)-2-(piperidin-4-yl)ethanoate monohydrochloride

Base Information

Chemical Name:ethyl (2RS)-2-(3,4-dichlorophenyl)-2-(piperidin-4-yl)ethanoate monohydrochloride
CAS No.:1207436-25-6
Molecular Formula:C₁₅H₁₉Cl₂NO₂*ClH
Molecular Weight:352.688
Hs Code.:

Synonyms:ethyl (2RS)-2-(3,4-dichlorophenyl)-2-(piperidin-4-yl)ethanoate monohydrochloride

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Chemical Property of ethyl (2RS)-2-(3,4-dichlorophenyl)-2-(piperidin-4-yl)ethanoate monohydrochloride

Chemical Property:

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Technology Process of ethyl (2RS)-2-(3,4-dichlorophenyl)-2-(piperidin-4-yl)ethanoate monohydrochloride

There total 7 articles about ethyl (2RS)-2-(3,4-dichlorophenyl)-2-(piperidin-4-yl)ethanoate monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1207438-63-8
tert-butyl 4-[(1RS)-1-(3,4-dichlorophenyl)-2-ethoxy-2-oxoethyl]piperidine-1-carboxylate

: 1207436-25-6
ethyl (2RS)-2-(3,4-dichlorophenyl)-2-(piperidin-4-yl)ethanoate monohydrochloride

Guidance literature:: With hydrogenchloride; ethanol; at 20 ℃; for 0.25h;
DOI:10.1016/j.bmc.2013.05.025

Reference yield:

: 1207438-43-4
tert-butyl 4-[(RS)-cyano(3,4-dichlorophenyl)methyl]piperidine-1-carboxylate

: 1207436-25-6
ethyl (2RS)-2-(3,4-dichlorophenyl)-2-(piperidin-4-yl)ethanoate monohydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen bromide; water / 5 h / Reflux

2.1: sodium hydroxide / water

2.2: 20 h / 20 °C

2.3: pH Ca_. 3

3.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

4.1: ethanol; hydrogenchloride / 0.25 h / 20 °C

With hydrogenchloride; ethanol; water; hydrogen bromide; potassium carbonate; sodium hydroxide; In water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.05.025

Reference yield:

: 1207438-51-4
(2RS)-2-(3,4-dichlorophenyl)-2-(piperidin-4-yl)ethanoic acid hydrobromide

: 1207436-25-6
ethyl (2RS)-2-(3,4-dichlorophenyl)-2-(piperidin-4-yl)ethanoate monohydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / water

1.2: 20 h / 20 °C

1.3: pH Ca_. 3

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: ethanol; hydrogenchloride / 0.25 h / 20 °C

With hydrogenchloride; ethanol; potassium carbonate; sodium hydroxide; In water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.05.025