diisopropyl 1,1-difluoro-10-(5-methyl-2,4-dihydropyrimidin-1,3(2H)-yl)decylphosphonate

Base Information

Chemical Name:diisopropyl 1,1-difluoro-10-(5-methyl-2,4-dihydropyrimidin-1,3(2H)-yl)decylphosphonate
CAS No.:1363335-74-3
Molecular Formula:C₂₈H₄₁F₂N₂O₆P
Molecular Weight:570.614
Hs Code.:

Synonyms:diisopropyl 1,1-difluoro-10-(5-methyl-2,4-dihydropyrimidin-1,3(2H)-yl)decylphosphonate

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Chemical Property of diisopropyl 1,1-difluoro-10-(5-methyl-2,4-dihydropyrimidin-1,3(2H)-yl)decylphosphonate

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Technology Process of diisopropyl 1,1-difluoro-10-(5-methyl-2,4-dihydropyrimidin-1,3(2H)-yl)decylphosphonate

There total 3 articles about diisopropyl 1,1-difluoro-10-(5-methyl-2,4-dihydropyrimidin-1,3(2H)-yl)decylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1363335-68-5
diisopropyl 1,1-difluoro-10-bromodecylphosphonate

: 4330-20-5
N-3-benzoylthymine

: 1363335-74-3
diisopropyl 1,1-difluoro-10-(5-methyl-2,4-dihydropyrimidin-1,3(2H)-yl)decylphosphonate

Guidance literature:: With N,N,N',N'-tetramethylguanidine; In dimethyl sulfoxide; acetonitrile; at 20 ℃; for 15h;
DOI:10.1021/jm201694y

Reference yield:

: 4549-33-1
1,9-Dibromononane

: 1363335-74-3
diisopropyl 1,1-difluoro-10-(5-methyl-2,4-dihydropyrimidin-1,3(2H)-yl)decylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.17 h / -78 °C

1.2: 1.5 h / -78 - -10 °C

2.1: N,N,N',N'-tetramethylguanidine / dimethyl sulfoxide; acetonitrile / 15 h / 20 °C

With tert.-butyl lithium; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; dimethyl sulfoxide; acetonitrile; pentane;
DOI:10.1021/jm201694y

Reference yield:

: 327156-97-8
diisopropyl (methylsulfanyl)difluoromethylphosphonate

: 1363335-74-3
diisopropyl 1,1-difluoro-10-(5-methyl-2,4-dihydropyrimidin-1,3(2H)-yl)decylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.17 h / -78 °C

1.2: 1.5 h / -78 - -10 °C

2.1: N,N,N',N'-tetramethylguanidine / dimethyl sulfoxide; acetonitrile / 15 h / 20 °C

With tert.-butyl lithium; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; dimethyl sulfoxide; acetonitrile; pentane;
DOI:10.1021/jm201694y